Research Progress on Mechanism of Autophagy in Prevention and Treatment of Diabetic Peripheral Neuropathy by Traditional Chinese Medicine
Diabetic peripheral neuropathy(DPN)has a long course and poor prognosis,with axonal degeneration and necro-sis,segmental demyelination of nerve fibers,apoptosis of Schwann cells nd other nerve cell injuries as the main pathological fea-tures.Autophagy is the cleaning mechanism of nerve cells,which eliminates damage caused by cellular stressors by clearing ex-cess metabolites,thereby maintaining intracellular homeostasis.The sustained high glucose environment alters the level of autoph-agy in the body.Inhibition or excessive activation of autophagy can cause irreversible damage to nerve cells,accelerate the pro-gression of DPN,restore autophagy balance,and thus reducing nerve damage.This is particularly crucial for the treatment of DPN.At present,there is no satisfactory treatment for DPN.In the process of prevention and treatment of DPN,traditional Chi-nese medicine has achieved good clinical effects with its unique advantages of multiple targets,multiple effects and multiple com-ponents.A large number of animal and clinical studies on the treatment of DPN by traditional Chinese medicine have shown that autophagy is an important target for the treatment of DPN by traditional Chinese medicine.Restoring autophagy balance can re-duce nerve injury,delay the process of nerve cell death and play a role in the prevention and treatment of DPN.However,its spe-cific mechanism is unknown.Based on this,this paper focused on the regulation of autophagy and its mechanism of action in the pathogenesis of DPN,as well as the intervention effect of single traditional Chinese medicine or compound effective ingredients on autophagy.It further explored the pathogenesis of DPN and potential therapeutic targets of traditional Chinese medicine interven-tion in autophagy,providing reference for further improving the efficacy of traditional Chinese medicine in treating DPN.
autophagydiabetic peripheralneuropathySchwann celltraditional Chinese medicineregulation and control mechanismreview
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