Research Progress on Blood Toxicity of Leigongteng(Tripterygium wilfordii Hook.f.)and Its Prevention
Leigongteng(Tripterygium wilfordii Hook.f.,TWHF)has a long history of medication.It has the effects of dis-pelling wind and dampness,promoting blood circulation and removing blood stasis,clearing heat and detoxification.It is often used in the treatment of various immune system diseases,and the curative effect is remarkable.As a traditional toxic Chinese medicine,its blood toxicity cannot be underestimated,which limits its application in many fields and has attracted more and more attention.By reviewing the related research of TWHF,combing and analyzing the characteristics of hematological toxicity,it is found that the clinical manifestations of patients are different.In severe cases,bone marrow suppression may occur,but the inci-dence is low and most of them are reversible.Due to its complex chemical composition,the mechanisms of blood toxicity caused by different components are different.In this paper,the main toxic components contained in TWHF were classified and sorted out,and the mechanism of its blood toxicity was summarized from the aspects of inhibiting cell cycle,affecting transcriptional reg-ulation,mutagenesis and inducing apoptosis.The prevention and treatment measures of traditional Chinese medicine and western medicine for TWHF attenuation were sorted out and explored,and the attenuation mechanism of single Chinese medicine,Chinese medicine compound and western medicine was summarized to provide reference and basis for its clinical use.
Tripterygium wilfordii Hook.f.hematotoxicitymechanism of actiontoxicity attenuation by compatibility
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