Guizhi Fuling Pill(桂枝茯苓丸)Treating Ovarian Cancer via Signaling Pathways:A Review
Guizhi Fuling Pill(桂枝茯苓丸),a classic traditional Chinese medicine(TCM)formula,has been verified in modern research to possess various pharmacological effects such as anti-fibrotic,anti-inflammatory,anti-tumor,modulating body immunity and improving cerebral ischemia effects.Ovarian cancer(OC)is one of the common malignant tumors of the fe-male reproductive system and is difficult to diagnose with few early symptoms and poor clinical outcomes in the late stages,posing a serious threat to women's health.By searching from such databases as China National Knowledge Infrastructure(CNKI),PubMed,Wanfang Data Knowledge Service Platform and Chongqing Weipu Database for Chinese Technical Periodicals(VIP),this article summarized the relevant pathways involved in the treatment of OC by Guizhi Fuling Pill and the main ingredients of its for-mula,and has found that they mainly involved phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR),Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3),Wnt/β-catenin,nu-clear factor kappa-B(NF-κB),vascular endothelial growth factor(VEGF)/vascular endothelial growth factor receptor 2(VEG-FR2)and Notch multiple signaling pathways.Guizhi Fuling Pill inhibits tumour cell proliferation,promotes apoptosis,blocks cell cycle and resists tumour angiogenesis through the above-mentioned signaling pathways to achieve good anti-tumour effects,pro-viding a strong basis for clinical prevention and treatment of OC and better reflecting the advantages of multiple pathways and tar-gets in the treatment of diseases by Chinese herbal medicine compound.
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