首页|益气化浊利水方联合针刺对气虚血瘀证2型糖尿病周围神经病变的疗效观察

益气化浊利水方联合针刺对气虚血瘀证2型糖尿病周围神经病变的疗效观察

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目的 探讨益气化浊利水方联合针刺治疗气虚血瘀证2型糖尿病周围神经病变(Type 2 diabetic peripheral neu-ropathy,T2DPN)的效果.方法 选取2021年9月-2022年9月医院收治的96例T2DPN患者为研究对象,以随机数字表法分研究组(48例)、对照组(48例).对照组给予针刺治疗,研究组在对照组基础上给予益气化浊利水方治疗,两组均持续治疗2周后评价效果.比较两组中医症状评分、周围神经传导速度及临床疗效,对比两组外周血炎症因子、氧化应激因子变化情况,记录两组治疗期间不良事件发生情况.结果 两组治疗后的主症、次症中医证候评分均低于治疗前(P<0.05),研究组治疗后中医证候评分均低于对照组(P<0.05).两组治疗后正中神经、胫后神经、腓总神经的运动神经传导速度(Motor nerve conduction velocity,MNCV)、感觉神经传导速度(Sensory nerve conduction velocity,SNCV)均高于治疗前(P<0.05),研究组治疗后上述指标均高于对照组(P<0.05).研究组总有效率(91.67%,44/48)高于对照组(77.08%,37/48)(P<0.05).两组治疗后肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、白细胞介素-6(Inter-leukin-6,IL-6)、C 反应蛋白(C-reactive protein,CRP)均低于治疗前(P<0.05),研究组治疗后的 TNF-α、IL-6、CRP均低于对照组(P<0.05).两组治疗后丙二醛(Malondialdehyde,MDA)均低于治疗前,超氧化物歧化酶(Superoxide dis-mutase,SOD)、总抗氧化能力(Total antioxidant capacity,TAOC)均高于治疗前(P<0.05),研究组治疗后的MDA均低于对照组,SOD、TAOC均高于对照组(P<0.05).两组总不良事件发生率比较,差异无统计学意义(P>0.05).结论 益气化浊利水方联合针刺治疗气虚血瘀证T2DPN可改善患者症状、周围神经传导速度,增强治疗效果,抑制外周血炎症因子分泌、减轻氧化应激损伤,安全性良好.
Observation on Curative Effect of Yiqi Huazhuo Lishui Formula(益气化浊利水方)Combined with Acupuncture on Type 2 Diabetes Peripheral Neuropathy with Qi Deficiency and Blood Stasis Syndrome
Objective To investigate the effect of Yiqi Huazhuo Lishui Formula(益气化浊利水方)combined with acupunc-ture on type 2 diabetes peripheral neuropathy(T2DPN)with Qi deficiency and blood stasis syndrome.Methods Ninety-six T2DPN patients admitted to the hospital from September 2021 to September 2022 were selected as the study objects and divided into study group(48 cases)and control group(48 cases)by random number table method.The control group was given acupunc-ture treatment,and the study group was additionally given Yiqi Huazhuo Lishui Formula.The effect was evaluated after 6 weeks of continuous treatment in both groups.The TCM symptom scores,peripheral nerve conduction velocity and clinical efficacy were compared between the two groups.The changes of inflammatory factors and oxidative stress factors in peripheral blood were com-pared between the two groups.The occurrence of adverse events during treatment was recorded in both groups.Results The TCM syndrome scores of the main and secondary symptoms of the two groups after treatment were lower than those before treatment(P<0.05)and the TCM syndrome scores of the main and secondary symptoms of the study group after treatment were lower than those of the control group(P<0.05).After treatment,the values of motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of median nerve,posterior tibial nerve and common peroneal nerve in two groups were higher than those before treatment(P<0.05),and the above indexes in the study group were higher than those in the control group(P<0.05).The total effective rate of the study group(91.67%,44/48)was higher than that of the control group(77.08%,37/48)(P<0.05).The levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)in the two groups after treatment were lower than those before treatment(P<0.05),and the levels of TNF-α,IL-6 and CRP in the study group after treatment were lower than those in the control group(P<0.05).The levels of malondialdehyde(MDA)after treatment in two groups were lower than those before treatment and the levels of superoxide dismutase(SOD)and total antioxidant capacity(TAOC)in two groups were higher than those before treatment(P<0.05).After treatment,the levels of MDA of the study group was lower than that of the control group,while the levels of SOD and TAOC of the study group were higher than those of the control group(P<0.05).There was no significant difference in the incidence of total adverse events in two groups(P>0.05).Conclusion In the treatment of T2DPN with Qi deficiency and blood stasis syndrome,Yiqi Huazhuo Lishui Formula com-bined with acupuncture can improve the clinical symptoms and peripheral nerve conduction velocity,enhance the therapeutic effect,inhibit the secretion of peripheral inflammatory factors,reduce the oxidative stress damage and has good safety.

type 2 diabetes mellitusdiabetic peripheral neuropathyQi deficiency and blood stasisacupunctureYiqi Hua-zhuo Lishui Formula(益气化浊利水方)effect

李艳秋、崔文旺

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安徽中医药大学附属太和中医院,安徽阜阳 236600

2型糖尿病 糖尿病周围神经病变 气虚血瘀 针刺 益气化浊利水方 效果

安徽省自然科学基金项目

1808084MH049

2024

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子:1.007
ISSN:1673-7717
年,卷(期):2024.42(4)
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