Observation on Curative Effect of Yiqi Huazhuo Lishui Formula(益气化浊利水方)Combined with Acupuncture on Type 2 Diabetes Peripheral Neuropathy with Qi Deficiency and Blood Stasis Syndrome
Objective To investigate the effect of Yiqi Huazhuo Lishui Formula(益气化浊利水方)combined with acupunc-ture on type 2 diabetes peripheral neuropathy(T2DPN)with Qi deficiency and blood stasis syndrome.Methods Ninety-six T2DPN patients admitted to the hospital from September 2021 to September 2022 were selected as the study objects and divided into study group(48 cases)and control group(48 cases)by random number table method.The control group was given acupunc-ture treatment,and the study group was additionally given Yiqi Huazhuo Lishui Formula.The effect was evaluated after 6 weeks of continuous treatment in both groups.The TCM symptom scores,peripheral nerve conduction velocity and clinical efficacy were compared between the two groups.The changes of inflammatory factors and oxidative stress factors in peripheral blood were com-pared between the two groups.The occurrence of adverse events during treatment was recorded in both groups.Results The TCM syndrome scores of the main and secondary symptoms of the two groups after treatment were lower than those before treatment(P<0.05)and the TCM syndrome scores of the main and secondary symptoms of the study group after treatment were lower than those of the control group(P<0.05).After treatment,the values of motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of median nerve,posterior tibial nerve and common peroneal nerve in two groups were higher than those before treatment(P<0.05),and the above indexes in the study group were higher than those in the control group(P<0.05).The total effective rate of the study group(91.67%,44/48)was higher than that of the control group(77.08%,37/48)(P<0.05).The levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)in the two groups after treatment were lower than those before treatment(P<0.05),and the levels of TNF-α,IL-6 and CRP in the study group after treatment were lower than those in the control group(P<0.05).The levels of malondialdehyde(MDA)after treatment in two groups were lower than those before treatment and the levels of superoxide dismutase(SOD)and total antioxidant capacity(TAOC)in two groups were higher than those before treatment(P<0.05).After treatment,the levels of MDA of the study group was lower than that of the control group,while the levels of SOD and TAOC of the study group were higher than those of the control group(P<0.05).There was no significant difference in the incidence of total adverse events in two groups(P>0.05).Conclusion In the treatment of T2DPN with Qi deficiency and blood stasis syndrome,Yiqi Huazhuo Lishui Formula com-bined with acupuncture can improve the clinical symptoms and peripheral nerve conduction velocity,enhance the therapeutic effect,inhibit the secretion of peripheral inflammatory factors,reduce the oxidative stress damage and has good safety.
type 2 diabetes mellitusdiabetic peripheral neuropathyQi deficiency and blood stasisacupunctureYiqi Hua-zhuo Lishui Formula(益气化浊利水方)effect