Research Progress on Anti-tumor Effects of Polyphyllin Ⅰ
Cancer is one of the major health challenges threatening the world.Chemotherapy and targeted therapy are impor-tant treatments for malignant tumors,but the severe side effects and drug resistance greatly affect patients'treatment compliance,quality of life and treatment efficacy.A lot of studies have revealed that traditional Chinese medicine is a natural treasure for ex-ploring novel anti-cancer therapies.The traditional Chinese herb Chonglou(Paridis Rhizoma),which belongs to the category of clearing heat and detoxifying herbs,is slightly cold and bitter,and has a mild toxicity.It has diverse medical effects,such as re-ducing swelling and pain,clearing heat and detoxifying.It is applicable for furuncle,sore throat,snake and insect bites,bruises and convulsions.Polyphyllin Ⅰ is the main bioactive component in Chonglou(Paridis Rhizoma).The chemical formula is C44H70 O16.Numerous experiments have shown that Polyphyllin Ⅰ can inhibit the growth of various malignant tumor cells by inhibiting tumor cell proliferation,blocking cell cycle,inducing apoptosis and autophagy,reversing tumor resistance,inhibiting tumor angio-genesis,inhibiting tumor EMT and regulating tumor microenvironment.Based on the relevant literatures of Polyphyllin Ⅰ in Chi-na and abroad,the present study reviewed the research progress of Polyphyllin Ⅰ to provide useful references for the further study of the anti-tumor effect of Polyphyllin Ⅰ and the development of novel anti-tumor drugs.
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