Research Progress on Anti-Tumor Signaling Pathway Relevant to Banzhilian(Scutellariae Barbatae Herba)
Banzhilian(Scutellariae Barbatae Herba)has a long history of medicinal use in China,and it has been proved by modern research that it contains flavonoids,polysaccharides,diterpenoids and other effective anti-tumor components.In this pa-per,it reviewed the literature on various signaling pathways of Banzhilian(Scutellariae Barbatae Herba)and its active components targeting tumor in recent years,and found that Banzhilian(Scutellariae Barbatae Herba)and its active components can regulate several signaling pathways,including phosphatidylinositol 3 kinase(PI3K)/protein kinase B(Akt),Janus kinase(JAK)/signal transducer and activator of transcription(STAT),Wnt/β-catenin,mitogen-activated protein kinase(MAPK),cysteinyl aspar-tate specific proteinase(caspase),nuclear factor kappa-B(NF-κB),P53 and Hedgehog.It can inhibit the proliferation of tumor cells,induce cell apoptosis,reduce migration and invasion ability,anti-tumor angiogenesis,regulate the immune function of the body and so on to achieve anti-tumor effect.It is widely used in the treatment of colon cancer,lung cancer,liver cancer,breast cancer and other tumor diseases.In this study,the cell signaling pathway was used as the breakthrough point to summarize the anti-tumor mechanism of Banzhilian(Scutellariae Barbatae Herba),in order to provide reference for further exploration of the anti-tumor mechanism of Banzhilian(Scutellariae Barbatae Herba)and its clinical application.
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