Research Progress of β-ecdysterone in Treatment of Osteoporosis in View of"Bone and Flesh Not Match"Theory
Osteoporosis is a systemic disorder of bone metabolism caused by imbalance of bone homeostasis.Commonly used drugs in clinical practice,such as bisphosphonates;denosumab and strontium ranelate,have adverse reactions such as gastrointes-tinal irritation and nephrotoxicity.Safe and long-term effective new drugs are urgently needed to fill the gap.In traditional Chi-nese medicine,osteoporosis belongs to the category of"bone flaccidity".Niuxi(Achyranthis Bidentatae Radix)is a common herb used in traditional Chinese medicine to treat"bone flaccidity".β-ecdysterone is the main active ingredient of Niuxi(Achyran-this Bidentatae Radix).This article systematically reviewed the treating mechanism of osteoporosis through β-ecdysterone and summarized the effects of increasing osteoblast activity,promoting osteogenic differentiation of bone marrow mesenchymal stem cells,increasing muscle mass and estrogen like substances by taking its regulation of bone and muscle molecules as a starting point,combined with the theory of traditional Chinese medicine and modern molecular medicine and biological research.
β-ecdysteroidNiuxi(Achyranthis Bidentatae Radix)bone and flesh not match theoryosteoporosisboneskel-etal muscle