Changes of CCL17 and YKL-40 in Allergic Rhinitis Patients Treated with Yiqi Zhiqiu Decoction(益气止鼽汤)Assisted Momitasone Furoate Nasal Spray
Objective To study the influence of Yiqi Zhiqiu Decoction(益气止鼽汤)assisted momesone furoate nasal spray in allergic rhinitis on CC chemokine ligand 17(CCL17)and chitinase protein-40(YKL-40).Methods A total of 88 patients with allergic rhinitis admitted to Jinan People's Hospital from December 2020 to December 2021 were selected and divided into two groups(44 cases in each group)by random number method.The nasal spray group was treated with mometasone furoate nasal spray.The Yiqi Zhiqiu Decoction group combined with Yiqi Zhiqiu Decoction on the basis of mometasone furoate nasal spray.The efficacy of the two groups after 4 weeks of treatment was compared,and the differences of CCL17,YKL-40 and other related factors between the two groups were detected,and the recurrence rate of the two groups after 3 months was analyzed.Results The total effective rate of Yiqi Zhiqiu Decoction group was 90.91％(40/44),higher than 75.00％(33/44)in the nasal spray group(P＜0.05).Before treatment,there was no statistical significance in CCL17,YKL-40,eosinophilic cationic protein(ECP)or inflammatory factors between the two groups(P＞0.05).Compared with those before treatment,the levels of CCL17,YKL-40,ECP,interleukin-4(IL-4),interleukin-17(IL-17)and tumor necrosis factor-α(TNF-α)were decreased in both groups after 4 weeks of treatment,and the levels were significantly lower in the Yiqi Zhiqiu Decoction group than those in the nasal spray group(P＜0.05).The recurrent rate of the Yiqi Zhiqiu Decoction group in 3 months was 6.82％(3/44),which was significantly lower than that in nasal spray group[22.73％(10/44)](P＜0.05).Conclusion Yiqi Zhiqiu Decoction assisted mometasone fu-roate nasal spray in the treatment of allergic rhinitis can alleviate inflammation,reduce the levels of CCL17,YKL-40 and ECP,improve the curative effect and reduce the recurrence rate.
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