Effects of Shugan Jieyu Capsule(疏肝解郁胶囊)Combined with Agomelatine on HAMD Score and OFQ and IL-2 in Patients with Depression
Objective To investigate the effects of Shugan Jieyu Capsule(疏肝解郁胶囊)combined with agomelatine on Ham-ilton Depression Rating Scale(HAMD)score,orphanin enkephalin(OFQ)and interleukin-2(IL-2)in patients with depres-sion.Methods Ninety patients with depression diagnosed were randomly divided into the control group and the test group,with 45 patients in each group.The control group was only given oral treatment of agomelatine,and the test group was given Shugan Jieyu Capsule and agomelatine.The treatment lasted for 3 months.The TCM symptom score,HAMD score,serum OFQ and IL-2 changes before and after treatment were observed to evaluate the therapeutic effect.Results There was no statistical difference in the scores of diet,spirit,defecation,sleep,tongue or pulse between the two groups before treatment(P＞0.05).After treatment,the scores of the two groups decreased compared with those before treatment(t=19.104,33.773,22.839,18.861,17.178 in the control group,t=43.690,48.830,45.737,39.032,31.847 in the test group),and the decline of the test group was greater than that of the control group(t=32.593,15.532,20.189,23.032,16.500),with statistical difference(P＜0.05).There was no sta-tistical difference in HAMD score before treatment between two groups(P＞0.05).After treatment,the score decreased compared with that before treatment(t=5.531 in the control group,t=8.930 in the test group),and the decrease in the test group was greater than that in the control group(t=5.360),with statistical difference(P＜0.05).There was no statistical difference in ser-um levels of OFQ or IL-2 between the two groups before treatment(P＞0.05).After treatment,the serum levels of OFQ and IL-2 decreased compared with those before treatment(t=7.099,4.204 in the control group,t=13.099,7.411 in the test group),and the decline range of the test group was greater than that of the control group(t=6.677,5.531),with statistical difference(P＜0.05).The total effective rate of treatment in the test group was 93.33％(42/45),which was higher than 77.78％(35/45)in the control group(P＜0.05).Conclusion Shugan Jieyu Capsule combined with agomelatine can significant-ly reduce the HAMD score and serum levels of OFQ and IL-2 in the treatment of depression.The therapeutic effect is better than that of agomelatine alone.
万方数据
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