N6-methyladenosine(m6A)modification is the most common epigenetic modification of eukaryotic messenger RNA(mRNA).In recent years,it has been found that m6A plays an important role in the occurrence and development of disea-ses.Through the retrieval and analysis of authoritative databases at home and abroad,this paper expounds the concept,mecha-nism and research background of m6A modification,and introduces the role of three kinds of methylases involved in regulating m6A modification in the process of m6A modification and their role in the occurrence and development of diseases.In addition,it systematically combs and summarizes the relevant research achievements of traditional Chinese medicine and its active compo-nents in preventing and treating diseases by interfering with m6A modification in recent years.Traditional Chinese medicine and its active ingredients are the valuable natural m6A regulators and have a good intervention effect in the prevention and treatment of cancer,cardiovascular diseases,reproductive system diseases and bone-related diseases,but its intervention in the prevention and treatment of diseases modified by m6A is still in the exploratory stage.Further exploration of its specific network regulation mechanism is undoubtedly a hot direction of traditional Chinese medicine research in the future.This paper can provide theoreti-cal reference and basis for further exploring the potential value of traditional Chinese medicine through m6A modification in the treatment of diseases and excavating and developing traditional Chinese medicine which can regulate epigenetics.
关键词
表观遗传学/mRNA/N6-甲基腺嘌呤/甲基化/中医药
Key words
epigenetics/mRNA/N6-methyladenine/methylation/traditional Chinese medicine
维普
万方数据