Research Progress of Traditional Chinese Medical Monomers in Treating Intervertebral Disc Degeneration by Promoting Autophagy of Nucleus Pulposus cells
Research Progress of Traditional Chinese Medical Monomers in Treating Intervertebral Disc Degeneration by Promoting Autophagy of Nucleus Pulposus cells
Intervertebral disc degeneration is a frequent clinical disease in which the primary pathological tissue and cell type are the nucleus pulposus and nucleus pulposus cells.When the nucleus pulposus cells experience accelerated aging or metabolic disorders due to pathological factors,the stability of the nucleus pulposus is disrupted,leading to the occurrence and development of intervertebral disc degeneration.Autophagy is one of the methods through which cells destroy aged organelles and aberrant pro-teins to maintain normal physiological functions under pathological circumstances.It can promote cell self-regulation to resist the influence of pathological factors.Nucleus pulposus cells are in an environment of stress and aberrant metabolism in the process of intervertebral disc degeneration.In order to prevent the buildup of toxic metabolites and slow down cell aging,it is beneficial to encourage autophagy in the nucleus pulposus cells.This helps to preserve the good physiological state of the nucleus pulposus and intervertebral discs.With the continuous deepening of research on the treatment of intervertebral disc degeneration diseases with traditional Chinese medicine,a large amount of monomeric components extracted from traditional Chinese herbs have been found to promote autophagy of nucleus pulposus cells to alleviate intervertebral disc degeneration.The relationship between the autophagy of nucleus pulposus cells and intervertebral disc degeneration was discussed in this paper based on the most recent research findings.Fourteen different traditional Chinese medicine monomers have been found to have promise in the field of en-couraging autophagy of nucleus pulposus cells to alleviate intervertebral disc degeneration.Due to their various effects,four mech-anisms can be summed up as follows:promoting autophagy to prevent nucleus pulposus cell apoptosis,promoting autophagy to combat nucleus pulposus cell oxidative stress,promoting autophagy to prevent the breakdown of nucleus pulposus extracellular ma-trix,and promoting autophagy to promote the molecular synthesis of nucleus pulposus extracellular matrix growth,so as to provide new ideas and references for the study of traditional Chinese medicine monomers regulating autophagy in nucleus pulposus cells and alleviating intervertebral disc degeneration.
关键词
自噬/髓核细胞/腰椎间盘退变/腰椎间盘突出症/中药单体
Key words
autophagy/nucleus pulposus cells/intervertebral disc degeneration/lumbar disc herniation/Chinese medicine monomer
维普
万方数据