Effects of Modified Shiying Yulin Decoction(石英毓麟汤加减)on Immune Regulation,Levels of AMH and FSH in Patients with Kidney Deficiency and Blood Stasis Polycystic Ovary Syndrome
Objective To explore the effects of Modified Shiying Yulin Decoction(石英毓麟汤加减)on immune regulation,the levels of anti-muller's tube hormone(AMH)and follicle stimulating hormone(FSH)in patients with polycystic ovary syn-drome(PCOS)with kidney deficiency and blood stasis.Methods A total of 78 patients with PCOS with kidney deficiency and blood stasis in the hospital from March 2021 to March 2022 were selected and divided into experimental group and control group with 39 cases in each by random number table method.The control group was given ethinylestradiol cyproterone tablets,and the experimental group was given Modified Shiying Yulin Decoction on the basis of the control group.Clinical efficacy,TCM symptom scores,B-ultrasound detection results,serum hormone indexes,peripheral blood NK cells,peripheral blood Th1/Th2 cytokines and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the experimental group was higher than that of the control group(P<0.05).After treatment,the two groups had less menstrual volume or amenor-rhea,decreased libido,dizziness and tinnitus,waist and knee tenderness,dysmenorrhea and decreased menstrual blood clot score(P<0.05).Compared with the control group,the experimental group had less menstrual volume or amenorrhea,decreased libi-do,dizziness and tinnitus,waist and knee tenderness,dysmenorrhea,and had lower menstrual blood clot content(P<0.05).Compared with those of the control group,the endometrial thickness and dominant follicle rate of the experimental group were higher after treatment(P<0.05).After treatment,the levels of luteinizing hormone(LH),FSH,testosterone(T)and AMH in the two groups were decreased,while the level of estrogen(E2)was increased(P<0.05).Compared with those of the control group,the levels of LH,FSH,T and AMH in the experimental group were lower,and the level of E2 was higher(P<0.05).After treat-ment,NK cells,the levels of interferon-γ(IFN-γ),interleukin-4(IL-4)and Th1/Th2 in both groups were decreased(P<0.05),and NK cells,the levels of IFN-γ,IL-4 and Th1/Th2 in the experimental group were lower than those in the control group(P<0.05).After treatment,the total incidence of adverse reactions in the experimental group was lower than that in the control group(P<0.05).Results Shiying Yulin Decoction has significant clinical effect in the treatment of PCOS with kidney de-ficiency and blood stasis.It can regulate the activity of NK cells in patients,correct the imbalance of Th1/Th2 cytokines,improve the condition of uterus and ovary,increase the ovulation rate and improve the hormone levels.
Modified Shiying Yulin Decoction(石英毓 麟汤加减)Polycystic ovary syndrome with kidney deficiency and blood stasisimmune regulationanti-muller's tube hormone(AMH)follicle stimulating hormone(FSH)