Clinical Efficacy and Safety of Qingwen Baiduyin Granules(清瘟败毒饮颗粒)Combined with Dipyridamole in Treatment of Kawasaki Disease in Children
Objective To analyze the clinical efficacy and safety of Qingwen Baiduyin Granules(清瘟败毒饮颗粒)combined with dipyridamole in the treatment of Kawasaki disease in children.Methods A total of 82 children with Kawasaki disease(Janu-ary 2019 to October 2022)admitted to the pediatric internal medicine department of the hospital were included in this study for grouping study.The grouping method was random number table method,and they were divided into Western medicine group and traditional Chinese medicine group,with 41 cases in each group.The Western medicine group was given dipyridamole treatment,and the traditional Chinese medicine group was treated with the same treatment method as the Western medicine group.Clinical treatment effect,integral changes of traditional Chinese medicine symptoms(strong heat,skin rash,red lips and dry cracks,red throat and eyes,joint pain,hand and foot swelling,etc),the incidence of coronary artery injury,the duration of fever,the regres-sion time of lymph node swelling and limb swelling,the regression time of mucosal congestion,the length of hospital stay,the changes of inflammatory factors such as procalcitonin(PCT),C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR),the immune indicators such as immunoglobulin G(IgG),immunoglobulin M(IgM)and complement C3(C3)as well as the occurrence of adverse reactions were observed.Results The total effective rate of traditional Chinese medicine group was high-er than that of the Western group(P＜0.05).The incidence of coronary artery injury in the traditional Chinese medicine group was lower than that in the Western medicine group(P＜0.05).The duration of fever,the regression time of lymph node enlarge-ment,the regression time of limb swelling,the regression time of mucosal congestion and the length of hospital stay in traditional Chinese medicine group were shorter than those in the Western medicine group(all P＜0.05).Before treatment,the scores of traditional Chinese medicine symptoms(strong heat,skin rash,red lips and dry cracks,red throat and eyes,joint pain,hand and foot swelling,etc),the levels of PCT,CRP,ESR,IgG,IgM,C3 and other indexes were not significant between two groups(P＞0.05).After treatment,the scores of traditional Chinese medicine symptoms(strong heat,skin rash,red lips and dry cracks,red throat and eyes,joint pain,hand and foot swelling,etc),the levels of PCT,CRP,ESR,IgG,IgM,C3 and other indexes were im-proved in both groups.And those in the traditional Chinese medicine group were all better than those in the Western group after treatment(P＜0.05).The rate of adverse reactions in the traditional Chinese medicine group and Western medicine group was lower(P＞0.05).Conclusion Qingwen Baiduyin Granules combined with dipyridamole have significant clinical efficacy in the treatment of Kawasaki disease in children,with improved symptoms,improved immune function,low incidence of coronary artery damage and fast recovery.It is safe and reliable treatment,worthy of application.
Kawasaki disease in childrenQingwen Baiduyin Granules(清瘟败毒饮颗粒)dipyridamoletherapeutic effectimmune functionadverse reaction
万方数据
维普
