Effect Observation on Kuntai Capsule(坤泰胶囊)Combined with Electroacupuncture in Treatment of Low Ovarian Reserve Function
Objective To observe the effect of Kuntai Capsule(坤泰胶囊)combined with electroacupuncture in the treatment of low ovarian reserve function.Methods A total of 109 patients with low ovarian reserve function admitted to the hospital from February 2019 to June 2021 were divided into observation group(55 cases)and control group(54 cases)by random number table method.The patients in the control group were treated with hormone cycle therapy,while those in the observation group were trea-ted with hormone cycle therapy and Kuntai Capsule combined with electroacupuncture cycle therapy.The clinical efficacy,the scores of TCM syndromes(delayed menstruation or low menstrual volume,amenorrhea,hypolibido,fatigue,etc.)before and after treatment,the levels of estradiol(E2),serum hormone such as follicle-stimulating hormone(FSH)and luteinizing hormone(LH),the changes in ovarian interstitial hemodynamic indexes,follicular development and adverse reactions and the pregnancy rate 1 year after treatment of two groups were compared.Results The total effective rates of control group and observation group were 81.48％and 94.55％,respectively(P＜0.05).Before treatment,the scores of TCM syndromes(delayed menstruation or low menstruation,amenorrhea,hypolibido,fatigue,etc.),the levels of E2,FSH and LH,the values of regular insulin index(RI)and pulsatility index(PI),the levels of maximum systolic blood flow velocity(Peak),peak systolic velocity(PS V),arterial systolic blood flow velocity/end-diastolic velocity(S/D)and other indicators of ovarian interstitial hemodynamics,the endometrial thick-ness and the thickness on ovulation day,the number of primary follicles and dominant follicles on ovulation day had no signifi-cance(P＞0.05).After treatment,the scores of TCM syndromes(delayed menstruation or low menstruation,amenorrhea,hypoli-bido,fatigue,etc.),the levels of E2,FSH and LH,the values of RI,PI,PSV and S/D,and the endometrial thickness and the thickness on ovulation day,the number of primary follicles and dominant follicles were improved.After treatment,the scores of TCM syndromes(delayed menstruation or low menstruation,amenorrhea,hypolibido,fatigue,etc.),the levels of E2,FSH and LH,the values of RI,PI,PSV and S/D,and the endometrial thickness and the thickness on ovulation day,the number of primary folli-cles and dominant follicles in the observation group were better than those control group(P＜0.05).The adverse rates of the ob-servation group and control group were lower(P＞0.05).The pregnancy rate of the observation group(47.27％,26/55)was higher than that of the control group(25.93％,14/54)after 1 year of treatment(P＜0.05).Conclusion Kuntai Capsule com-bined with electroacupuncture cycle therapy has a significant effect on the low ovarian reserve function.The patients'symptoms recovered well and the ovarian function recovered well.The patients have a high pregnancy rate in the next year,and there are fe-wer adverse reactions.It is safe and reliable,and is worthy of applying.
万方数据
维普
