Clinical Effect of Modified Yupingfeng Powder(玉屏风散加减)Combined with Acupuncture at Different Menstrual Cycle Phases for Recurrent Implantation Failure of In Vitro Fertilization Embryo Transfer
Objective To investigate the clinical therapeutic value of Modified Yupingfeng Powder(玉屏风散加减)combined with acupuncture at different menstrual cycle phases for recurrent implantation failure(RIF)patients undergoing pre implantation genetic screening(PGS)in vitro fertilization embryo transfer(IVF-ET).Methods One hundred and seventy-three patients with RIF in the hospital from January 2020 to January 2022 were enrolled,and classified into three groups according to random number table methods.The control group(41 cases)received conventional hormonal therapy.The observation group 1(37 cases)received Modified Yupingfeng Powder combined with hormonal therapy.The observation group 2(44 cases)received acupuncture at different menstrual cycle phases combined with hormonal therapy.The observation group 3(51 cases)received Modified Yup-ingfeng Powder combined with acupuncture at different menstrual cycle phases and hormonal therapy.Then the endometrial re-ceptivity[endometrial thickness,vascularization flow index(VFI),vascularization index(VI),flow index(FI)],anxiety and de-pression scores,biochemical pregnancy rate,clinical pregnancy rate,early miscarriage rate,ectopic pregnancy rate,and live birth rate were analyzed in each group.Results After treatment,the endometrial thickness,the values of VFI,VI and FI of the observa-tion group 3 were higher than those of the control group(P＜0.05).Each observation group scored higher on Hamilton Depres-sion Scale(HAMD)and Hamilton Anxiety Scale(HAMA)than control group,with statistical difference(P＜0.05).The bio-chemical pregnancy rate and clinical pregnancy rate of the observation group three were higher than those of the control group,and the live birth rate of each observation group was higher than that of control group(P＜0.05).No statistical difference was found in the early miscarriage rate and ectopic pregnancy rate among the groups(P＞0.05).Conclusion Yupingfeng Powder combined with acupuncture at different menstrual cycle phases for RIF patients can effectively increase the biochemical pregnancy rate,clin-ical pregnancy rate and live birth rate.The mechanism may be related to improving endometrial thickness,increasing uterine he-modynamic parameters,promoting endometrial growth,improving endometrial tolerance and alleviating anxiety and depression,thus improving pregnancy outcome in patients with RIF.
万方数据
维普
