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肝主生发的理论创新及其诊疗体系构建与应用

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肝主生发的理论创新为肝脏及其相关病证的防治提供了中医肝藏象新的理论基础，"髓生肝""髓失生肝""补肾生髓成肝"是其重要知识体系，中医药调控发生发育及再生修复防治肝脏及其相关病证是其主要研究内容，在获得提高临床疗效的较高级别循证医学证据和明确疗效机制的基础上构建诊疗体系:病程进展的评估监测、识病辨证的诊疗标准、整体动态的防治方案和肝主生发的创新方药。该理论降低了慢性肝病患者肝硬化发生率，降低了肝癌发生风险及发生率，降低了肝衰竭的发生率，降低了慢加急性肝衰竭和慢性肝衰竭患者的病死率，减少或减轻了并发症，提高了艾滋病患者免疫功能重建能力，提高了患者生存质量，提高了中医药防治肝脏及其相关病证的能力和水平，体现其理论意义和临床价值。
Theoretical Innovation of Liver Governing Growth and Construction and Application of Its Diagnosis and Treatment System
The theoretical innovation of liver governing growth provides a new theoretical basis of viscera-state of traditional Chinese medicine(TCM)for the prevention and treatment of liver and related diseases.The important knowledge systems include"marrow stem cells differentiating into liver cells","marrow stem cells failing to differentiate into liver cells"and"tonifying kid-ney to promote liver regeneration and repair by effecting stem cells and their microenvironment".The main research content is TCM regulating the occurrence,development,regeneration and repair for the prevention and treatment of liver and related disea-ses.On the basis of obtaining high-level evidence-based medicine evidence to improve the clinical efficacy and clarifying the mechanism of efficacy,a diagnosis and treatment system is constructed:Evaluating and monitoring the disease progress,diagnosis and treatment standards for disease identification and syndrome differentiation,overall dynamic prevention and treatment programs and innovative prescriptions for liver governing growth.It has reduced the incidence of cirrhosis in patients with chronic liver dis-ease,the risk and incidence of liver cancer,the incidence of liver failure and the mortality of patients with acute-on-chronic liver failure and chronic liver failure,reduced or alleviated the complications,improved the immune function reconstruction ability of AIDS patients,the quality of life of the patients and the ability and level of TCM to prevent and treat liver and its related disea-ses and syndromes.These reflect its theoretical significance and clinical value.

liver governing growththeoretical innovationdiagnosis and treatment system

李瀚旻

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湖北省中医院肝病研究所,湖北中医药大学附属医院,湖北省中医药研究院中医基础理论研究所,国家中医药管理局细胞分子生物学三级实验室,国家中医药管理局慢性肝病肝肾论治重点实验室,中医肝肾研究及应用湖北省重点实验室,湖北武汉 430061

肝主生发 理论创新 诊疗体系

国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金国家中医临床研究基地(湖北)重点病种研究项目李瀚旻湖北中医名师传承工作室项目广西中医药局重症肝病多学科交叉创新团队项目

819736698177428081703912816034848157381581274147JDZX2015172鄂卫生计生办通[2018]32号GZKJ2306

2024

10.13193/j.issn.1673-7717.2024.06.001

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子：1.007
ISSN：1673-7717
年,卷(期)：2024.42(6)
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