Effects of Shensong Yangxin Capsule(参松养心胶囊)Combined with Sacubatro Valsartan on hs-CRP,BNP,Ang Ⅱ and Cardiac Function in Treatment of Paroxysmal Atrial Fibrillation Complicated with Chronic Heart Failure
Objective To investigate the effects of Shensong Yangxin Capsule(参松养心胶囊)combined with sacubatro val-sartan on high-sensitivity C-reactive protein(hs-CRP),brain natriuretic peptide(BNP),angiotensin Ⅱ(Ang Ⅱ)and cardi-ac function in the treatment of paroxysmal atrial fibrillation complicated with chronic heart failure.Methods A hundred cases with paroxysmal atrial fibrillation complicated with chronic heart failure were selected and randomly divided into control group and ob-servation group,50 cases in each group.The control group was given sacubatro valsartan orally on the basis of the conventional treatment.The observation group was given Shensong Yangxin Capsule combined with sacubatro valsartan orally on the basis of the conventional treatment.The treatment course lasted for 6 months.The changes of serum hs-CRP,BNP,Ang Ⅱ,left ventricu-lar ejection fraction(LVEF),left ventricular end systolic diameter(LVESD)and left ventricular end diastolic diameter(LVEDD)were observed.Results There were no significant differences in serum hs-CRP,BNP or Ang Ⅱ between the two groups before treatment(P＞0.05)and the indexes decreased after treatment(P＜0.05).The levels of serum hs-CRP,BNP and Ang Ⅱ in the observation group were lower than those of the control group(P＜0.05).There were no significant differences in LVEF,LVESD or LVEDD between the two groups before treatment(P＞0.05).LVEF increased after treatment(P＜0.05),and that in the observation group was higher than that in the control group(P＜0.05),LVESD and LVEDD decreased after treatment(P＜0.05),and those in the observation group were lower than those of he control group(P＜0.05).There was no significant differ-ence in the number of paroxysmal atrial fibrillation,duration of paroxysmal atrial fibrillation or ventricular rate between the two groups before treatment(P＞0.05).These indexes decreased after treatment(P＜0.05),and the indexes in the observation group were lower than those of the control group(P＜0.05).The mortality rates of persistent atrial fibrillation,worsening heart failure and absence of heart source were 20.00％,22.00％and 4.00％in the control group,and 4.00％,6.00％and 0.00％in the observation group,respectively.The incidence of persistent atrial fibrillation and worsening heart failure in the control group was higher than that in the observation group(P＜0.05).The therapeutic effect of the observation group was better than that of the control group(P＜0.05).Conclusion Shensong Yangxin Capsule combined with sacubatro valsartan can promote the decrease of hs-CRP,BNP and Ang Ⅱ in the treatment of paroxysmal atrial fibrillation complicated with chronic heart failure and improve the cardiac function and prognosis of patients.
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