Study on Clinical Effect and Partial Mechanism of Erlong Zuoci Pills(耳聋左慈丸)in Treating Chronic Secretory Otitis Media
Objective To observe the clinical effect of Erlong Zuoci Pills(耳聋左慈丸)combined with conventional western medicine in the treatment of chronic secretory otitis media and to analyze its mechanism.Methods A total of 200 patients with chronic secretory otitis media treated in otolaryngology department of the hospital from January 2022 to December 2022 were se-lected and divided into control group and experimental group by random number table method,with 100 cases in each group.The patients in the control group were given conventional Western medicine treatment,and those in the experimental group were given Erlong Zuoci Pills on the basis of the control group.The clinical efficacy,symptoms and adverse reactions of the two groups were compared as well as the changes of hearing level and the levels of inflammatory factors in ear effusion before and after treatment.Results The effective rate of the control group was 80.00％(80/100)and that of the experimental group was 90.00％(90/100).Compared with that of the control group,the effective rate of the experimental group was significantly increased(P＜0.05).There was no significant difference in the seven-item eustachian tube dysfunction questionnaire(ETDQ-7)between the two groups before treatment and 1 week after treatment(P＞0.05).After 3 weeks of treatment,the ETDQ-7 level of the experimental group was significantly decreased compared with that of the control group(P＜0.01).After the intervention,the scores of tinnitus,ear tightness,hearing loss and tympanic effusion in the experimental group were significantly decreased compared with those in the control group(P＜0.01).After the intervention,compared with those of the control group,the pure tone hearing thresholds of 0.5,1 and 2 kHz in the experimental group were significantly decreased,and the difference was statistically significant(P＜0.01).Before intervention,there was no significant difference in the levels of inflammatory factors in ear effusion between the two groups(P＞0.05).After the intervention,the levels of interleukin-1β(IL-1β),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in ear effusion of the experimental group were significantly decreased compared with those of the control group(P＜0.01).During the intervention,the main adverse reactions of all patients included nausea,vomiting,loss of appetite,abdominal pain,diarrhea,dizziness and headache,and there was no significant difference in the incidence of adverse reactions be-tween the two groups(P＞0.05).Conclusion Erlong Zuoci Pills combined with conventional Western medicine therapy in the treatment of chronic secretory otitis media has good clinical effect,and can improve the hearing level and the clinical symptoms,and inhibit the local inflammatory reaction of the patients,and there was no increased adverse reaction.
万方数据
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