目的 观察芍麻止痉颗粒治疗儿童抽动症的临床疗效。方法 选择2019年1月—2022年5月在医院儿内科住院治疗的80例儿童抽动症患儿作为研究对象，按照不同治疗方法将患儿分为常规组和观察组，各组40例，常规组患儿单纯予以氟哌啶醇片治疗，观察组患儿在常规组基础上联合芍麻止痉颗粒治疗。观察两组患儿的临床效果、不良反应及复发率，比较干预前后血清神经因子水平和免疫功能变化。结果 常规组患者的有效率为80。00％，观察组患者的有效率为95。00％，与常规组比较，观察组的有效率明显升高(P＜0。05)。干预3个月后，与常规组比较，观察组患儿的血清神经生长因子(nerve growth factor，NGF)和γ-氨基丁酸(γ-aminobutyric acid，GABA)水平明显升高，而5-羟色胺(5-hydroxytryptamine，5-HT)、多巴胺(dopamine，DA)、神经元特异性醇化酶(neuron specific alcoholase，NSE)、谷氨酸(gluta-mate，GLU)水平明显下降(P＜0。01);观察组患儿外周血中CD3+、CD4+以及CD4+/CD+水平明显升高，而CD8+水平则明显下降(P＜0。01，P＜0。05)。且观察组患儿的耶鲁综合抽动严重程度量表(Yale global tic severity scale，YGTSS)评分和基于案例的协作学习(case-based collaborative learning，CBCL)评分相较于常规组明显降低，差异具有统计学意义(P＜0。01)。治疗期间两组患儿的主要不良反应有口干、消化不良、头晕、乏力、皮疹等，常规组和观察组的不良反应总发生率分别为12。50％、17。50％，差异无统计学意义(P＞0。05)。治疗后3、6个月两组患儿的复发率差异无统计学意义(P＞0。05);观察组患儿的总复发率(7。50％)相较于常规组(25。00％)明显降低(P＜0。05)。结论 芍麻止痉颗粒联合氟哌啶醇片能够提高儿童抽动症作患儿的临床疗效、降低复发率，提高患儿的免疫功能，调节神经因子水平，且无不良反应增加。
Clinical Study of Shaoma Zhasu Granule(芍麻止痉颗粒)in Treatment of Tourette Syndrome in Children
Objective To observe the clinical effect of Shaoma Zhasu Granule(芍麻止痉颗粒)in the treatment of Tourette syndrome in children.Methods A total of 80 children with Tourette syndrome hospitalized in pediatrics department of the hospital from January 2019 to May 2022 were selected as research objects.According to different treatment methods,the children were e-venly divided into the conventional group and the observation group,with 40 cases in each group.The conventional group was treated with haloperidol tablets alone,and the observation group was treated with Shaoma Zhasu Granule on the basis of the con-ventional group.The clinical effects,adverse reactions and recurrence rate of the two groups were observed,and the changes of serum neurofactor levels and immune function before and after intervention were compared.Results The effective rate of the con-ventional group was 80.00％,and that of the observation group was 95.00％.Compared with that of the conventional group,the effective rate of the observation group was significantly increased(P＜0.05).After 3 months of intervention,compared with those of the conventional group,the serum levels of nerve growth factor(NGF)and gamma-aminobutyric acid(GABA)in the observa-tion group were significantly increased.While the levels of 5-hydroxytryptamine(5-HT),dopamine(DA),neuron specific al-coholase(NSE)and glutamate(GLU)were significantly decreased(P＜0.01).In the observation group,the levels of CD3+♂,CD4+♂ and CD4+♂/CD8+♂ in the peripheral blood were significantly increased,while the levels of CD8+♂ were significantly de-creased(P＜0.01,P＜0.05).Yale global tic severity scale(YGTSS)scores and case-based collaborative learning(case-based collaborative learning)scores were obtained in the observation group.The CBCL score was significantly lower than that of the conventional group,and the difference was statistically significant(P＜0.01).The total incidence of adverse reactions in the conventional group and the observation group was 12.50％and 17.50％,respectively,with no statistical significance(P＞0.05).There was no significant difference in the recurrence rate of 3 and 6 months after treatment(P＞0.05).The total recurrence rate in the observation group(7.50％)was significantly lower than that in the conventional group(25.00％)(P＜0.05).Conclusion Shaoma Zhasu Granule combined with Haloperidol Tablets can improve the clinical efficacy,reduce the recurrence rate,improve the immune function and regulate the level of neurofactors in children with Tourette syndrome without increasing adverse reac-tions.
万方数据
维普
