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薯蓣丸抗肿瘤的作用机制和临床研究进展

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薯蓣丸出自《金匮要略》,具有益气养血、扶正补虚、祛风除邪之功,是治疗虚劳诸疾的经典方剂,现代医家扩展应用于肿瘤疾病中,收到了满意疗效。整理近20年中英文文献,从分子机制和临床研究两方面总结薯蓣丸在肿瘤疾病中的应用,发现薯蓣丸抗肿瘤的机制主要包括抑制肿瘤细胞增殖,促进凋亡,抗肿瘤转移,改善肿瘤微环境,调节免疫紊乱等,分子机制明确;临床作用主要体现在促进食欲、改善恶病质状态,缓解临床症状,辅助西医减毒增效和增强免疫、提高患者生存质量等,收效良好,且价格低廉、安全无毒,适合肿瘤患者长期服用,可在临床推广。通过文献归纳对薯蓣丸治疗肿瘤的现状进行了全面分析,并对当今实验和临床研究提出不足与改进之处,以期为该方后续深入研究和肿瘤治疗新模式开展提供相关依据和支持。
Research Progress in Anti-Tumor Mechanism and Clinical Treatment Research of Shuyu Pill(薯蓣丸)
Shuyu Pill(薯蓣丸)in Synopsis of The Golden Chamber(Jingui Yaolue)has the effect of nourishing Qi and blood,supporting the healthy Qi and replenishing deficiency and dispelling wind and evils,it is a classic prescription to treat all kinds of consumptive diseases.Modern doctors have extended the application to tumor diseases,and also have received satisfacto-ry curative effect.This paper summarized the application of Shuyu Pill in tumor diseases from the molecular mechanism and clini-cal research.It is found that the anti-tumor mechanism of Shuyu Pill mainly includes inhibiting tumor cell proliferation,promo-ting apoptosis,anti-tumor metastasis,improving the tumor micro-environment,regulating immune disorder and so on,the mo-lecular mechanism is clear.The clinical effects mainly reflect in promoting appetite,improving cachexia status,relieving clinical symptoms,assisting western medicine to attenuate toxicity and enhance immunity,improving the quality of life of patients and so on with good results,low price,safe and non-toxic,being suitable for long-term use of tumor patients and can be promoted in clinical practice.In this paper,the current status of Shuyu Pill in the treatment of cancer was comprehensively analyzed by litera-ture induction and the deficiencies and improvements of current experimental and clinical studies were proposed,in order to pro-vide relevant basis and support for the subsequent in-depth research of this prescription and the development of a new model of tumor treatment.

Shuyu Pill(薯蓣丸)malignant tumorresearch progressmechanism of actionreview

朱燃培、刘梦雅、郑玉玲

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河南中医药大学,河南郑州 450046

薯蓣丸 恶性肿瘤 研究进展 作用机制 综述

全国名老中医药专家传承工作室建设项目国家中医药局全国名中医传承工作室建设项目

国中医药人教函[2022]75号国中医药人教函[2022]245号

2024

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子:1.007
ISSN:1673-7717
年,卷(期):2024.42(6)
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