首页|切制工艺小试与中试的比较及思考——以黄芩饮片为例

切制工艺小试与中试的比较及思考——以黄芩饮片为例

扫码查看
原文链接
  • 万方数据
  • 维普
目的 采用实验室小试和饮片厂中试工艺对黄芩药材进行切制，比较两种工艺的差异，为黄芩片的生产加工标准化提供参考。方法 采用《中华人民共和国药典》(2020年版)黄芩的浸出物及含量测定方法，对黄芩药材及饮片醇溶性浸出物和黄芩苷的含量进行测定;采用课题组前期建立的黄芩高效液相色谱法(High Performance Liquid Chromatogra-phy，HPLC)指纹图谱方法对黄芩药材及饮片进行测定;对小试和中试得到的黄芩片进行饮片得率、外观性状、浸出物和黄芩苷含量、指纹图谱及成分转移率的比较。结果 采用小试和中试工艺得到的黄芩片均为薄片，片型相近，外表皮为黄棕色，具有放射状纹理，且浸出物和黄芩苷含量均符合《中华人民共和国药典》规定。小试工艺的饮片得率、浸出物和黄芩苷转移率比中试工艺略高。结论 小试工艺和中试工艺得到的黄芩片质量相对稳定，切制工艺参数设置合理。在黄芩药材的切制工艺中，环境温湿度、水洗次数和蒸制压力是关键因素。小试研究和中试验证的结合，可降低饮片工业化生产风险，为黄芩片的生产加工标准化提供参考。
Comparison and Thinking of Bench Scale Test and Pilot Test of Cutting Technology——Taking Huangqin(Scutellariae Radix)Pieces As An Example
Objective In order to provide a reference for the standardization of production and processing of Huangqin(Scutel-lariae Radix)pieces,the laboratory bench scale test and herbal pieces factory pilot test were used to cut Huangqin(Scutellariae Radix)and two tests were compared.Methods The contents of alcohol soluble extract and baicalin in Huangqin(Scutellariae Ra-dix)and its decoction pieces were determined by the extraction and content determination method of Huangqin(Scutellariae Ra-dix)in Chinese Pharmacopoeia(2020).To investigate the HPLC fingerprint of Huangqin(Scutellariae Radix)and its decoction pieces by using the fingerprint method of Huangqin(Scutellariae Radix)by the laboratory in the early stage.The yield of pieces,appearance,content of extract and baicalin,fingerprint chromatogram and component transfer rate of Huangqin(Scutellariae Ra-dix)pieces in bench scale test and pilot test were compared.Results The Huangqin(Scutellariae Radix)pieces obtained in the bench scale test and pilot test were slices,with similar shape,the outer skin was yellow-brown,with radial texture,and the con-tents of extract and baicalin met the requirements of pharmacopoeia.The yield of slices,extract and baicalin transfer rate of the bench scale process were slightly higher than those of the pilot process.Conclusion The qualities of Huangqin(Scutellariae Ra-dix)pieces obtained by the bench scale test and pilot test are relatively stable,and the cutting process parameters are set reasona-bly.In the cutting process of Huangqin(Scutellariae Radix),environmental temperature and humidity,the washing and steaming pressure are key factors.The combination of bench scale test and pilot test can reduce the risk of industrialized production of de-coction pieces and provide a reference for the standardization of production and processing of Huangqin(Scutellariae Radix).

Huangqin(Scutellariae Radix)cutting technologysofteningmoisteningbench scale testpilot testcomparative study

贾哲、刘艳萍、张晴、张村

展开 >

中国中医科学院中药研究所,北京 100700

河南中医药大学药学院,河南郑州 450008

黄芩 切制工艺 软化 润制 小试 中试 比较研究

国家自然科学基金国家中医药局中药炮制技术传承基地项目中国中医科学院中药研究所人才引进项目中国中医科学院科技创新工程重大攻关项目

82173979国中医药科技中药[2022]59号ZXKT21027CI2021A04208

2024

10.13193/j.issn.1673-7717.2024.06.027

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子：1.007
ISSN：1673-7717
年,卷(期)：2024.42(6)
  • 26