Prospective Study on Effect of Qinggan Ningwei Prescription(清肝宁胃方)Assisted Mosaprid with Bile Reflux Gastritis under Gastroscope
Objective To investigate the effect of Qinggan Ningwei Prescription(清肝宁胃方)assisted mosapride on bile re-flux and gastrointestinal hormone expression in patients with bile reflux gastritis(BGR)under gastroscopy,in order to provide a reference for clinical treatment.Methods From January 2020 to January 2023,a prospective randomized controlled study method was used to select 118 BGR patients in the hospital.And they were divided into an integrated traditional Chinese and western medicine group(59 cases)and a western medicine group(59 cases).The western medicine group was given mosapride,and the integrated traditional Chinese and western medicine group was given Qinggan Ningwei Prescription assisted with mosapride,and both were treated for 1 month.The efficacy and adverse reactions,the scores of TCM syndromes,bile reflux under gastroscopy,the levels of serum inflammatory factors[interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)]and gastrointestinal hormone[gastrin(GAS),motilin(MTL)]before and one month after treatment were compared between the two groups.Results(1)Curative effect:After treatment,the total effective rate of the integrated traditional Chinese and western medicine group was 93.22％,which was higher than 79.66％of the western medicine group(P＜0.05).(2)TCM syndrome scores and gastroscopic bile reflux:The scores of TCM syndromes in the two groups were lower than those before treatment after 1 month of treatment,and the scores of the integrated traditional Chinese and western medicine group were lower than those of the western medicine group.The condition of bile reflux under gastroscopy was improved compared with that before treatment,and the condition of integrated traditional Chinese and western medicine group was better than that of the western medicine group(P＜0.05).(3)Inflammatory factors and gastrointestinal hormones:The levels of serum IL-8,TNF-α,CRP and GAS in the two groups were lower than those before treatment after 1 month of treatment,and the levels in the integrated traditional Chinese and western medicine group were lower than those in the western medicine group.The level of MTL was higher than that before treat-ment,and the level of the integrated traditional Chinese and western medicine group was higher than that of the western medicine group(P＜0.05).(4)Adverse reactions:The adverse reaction rate was 5.08％in the integrated traditional Chinese and western medicine group and that was 8.47％in the western medicine group,and the difference was not statistically significant(P＞0.05).Conclusion The application of Qinggan Ningwei Prescription with mosapride in the treatment of BGR patients can improve the bile reflux and gastrointestinal hormone expression under gastroscope,reduce the body''s inflammation and clinical symptoms,enhance the efficacy and has good safety.
Qinggan Ningwei Prescription(清肝宁胃方)mosapridebile reflux gastritisbile reflux under gastroscopygas-trointestinal hormones
万方数据
维普
