Efficacy Observation and Safety Evaluation of Tongqiao Tuomin Prescription(通窍脱敏方)in Treatment of Allergic Rhinitis
Objective To observe the curative effect and evaluate the safety of Tongqiao Tuomin Prescription(通窍脱敏方)in the treatment of allergic rhinitis.Methods A total of 82 AR patients who were diagnosed as having lung-Qi deficiency and cold syndrome in Otorhinolaryngology Department of Hebei Provincial Hospital of Traditional Chinese Medicine from July 2021 to July 2022 were selected as the research subjects.They were equally divided into the observation group and the control group by using the random number method.The control group was treated with oral administration of loratadine tablets,and the observation group was given self-made Tongqiao Tuomin Prescription.The TCM syndrome scores,clinical efficacy differences and adverse reac-tions between the two groups were compared before treatment and two or four weeks after treatment.Besides,the recurrence cases of the two groups were compared after a follow-up of six months.Results The total effective rate in the observation group was significantly higher than that in the control group(P＜0.05).With the prolongation of treatment time,the main symptoms,sec-ondary symptoms and the total score in the two groups were gradually decreased(P＜0.05).The main symptoms,secondary symptoms and total scores in the observation group after two and four weeks of treatment were lower than those in the control group(P＜0.05).With the prolongation of treatment time,the serum levels of total immunoglobulin E(IgE),eosinophil count and in-terleukin 17(IL-17)of patients in the two groups were gradually decreased(P＜0.05).The serum levels of total IgE,eosino-phil count and IL-17 in the observation group were lower than those in the control group at two and four weeks after treatment(P＜0.05).There was no difference in the adverse reactions between the two groups(P＞0.05).There was no difference in the recurrence rate within three months between the two groups(P＞0.05).The recurrence rate in the observation group was lower than that in the control group six months after treatment(P＜0.05).Conclusion Tongqiao Tuomin Prescription has better clinical efficacy in the treatment of allergic rhinitis,which can improve the symptoms of rhinitis in patients more quickly and reduce the inflammatory reaction of the body better.It not only has less adverse reactions,but also greatly reduces the long-term recur-rence,and is worthy of clinical application.
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