津力达颗粒联合司美格鲁肽对2型糖尿病合并冠心病糖脂代谢、心脏功能及血管内皮功能的影响
Effects of Jinlida Granules(津力达颗粒)Combined with Simeglutide on Glucose and Lipid Metabolism,Cardiac Function and Vascular Endothelial Function in Patients with Type 2 Diabetes Mellitus Complicated with Coronary Heart Disease
侯丽萍 1耿建林 1谷巍 1张雪坤1
作者信息
- 1. 衡水市人民医院,河北衡水 053000
- 折叠
摘要
目的 观察津力达颗粒联合司美格鲁肽对2型糖尿病合并冠心病患者糖脂代谢、心脏功能及血管内皮功能的影响.方法 选择2022年7月—2023年1月于医院内分泌科就诊的100例2型糖尿病合并冠心病患者作为研究对象,随机分为对照组和试验组,各50例,对照组应用抗凝、预防心绞痛等冠心病基础治疗,联合二甲双胍、司美格鲁肽降糖治疗,试验组在对照组基础上予以口服津力达颗粒.观察并比较两组患者的临床疗效,以及干预前后的糖脂代谢水平、血管内皮功能及心脏功能.结果 对照组患者的有效率为80.00％(40/50),试验组患者的有效率为94.00％(47/50),与对照组比较,试验组的有效率明显升高(P＜0.05).治疗3个月后,试验组患者的空腹血糖(fasting blood glucose,FBG)、餐后 2 h 血糖(2-hour postprandial blood glucose,2 hPG)以及糖化血红蛋白(glycosylated hemoglobin,HbA1C)水平相较于对照组均明显降低(P＜0.05).治疗前两组患者的血脂水平差异无统计学意义(P＞0.05).治疗3个月后,相较于对照组,试验组患者总胆固醇(total cholesterol,TG)、甘油三酯(triglyceride,TG)以及低密度脂蛋白胆固醇(low density lipopro-tein cholesterol,LDL-C)水平均明显降低,而高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)水平则明显升高(P＜0.01,P＜0.05);试验组患者的左室射血分数(left ventricular ejection fraction,LVEF)、每搏输出量(stroke vol-ume,SV)以及左室舒张早期/晚期峰值速率比值(left ventricular early/late diastolic peak rate ratio,E/A)水平相较于对照组均明显升高(P＜0.01).治疗前两组患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)、一氧化氮(nitric oxide,NO)以及内皮素-1(endothelin-1,ET-1)水平差异无统计学意义(P＞0.05).干预后试验组患者血清中VEGF和NO水平相较于对照组明显升高,而ET-1水平则明显下降(P＜0.01).干预过程中两组患者的主要不良反应有皮疹、头痛、低血糖以及胃肠道不适等,但两组患者的不良反应总发生率差异无统计学意义(P＞0.05).结论 津力达颗粒联合司美格鲁肽能够明显提高2型糖尿病合并冠心病患者的临床疗效,调节糖脂代谢紊乱,保护心脏及血管内皮功能.
Abstract
Objective To observe the effects of Jinlida Granules(津力达颗粒)combined with simeglutide on glucose and lipid metabolism,cardiac function and vascular endothelial function in patients with type 2 diabetes mellitus complicated with coronary heart disease.Method A total of 100 patients with type 2 diabetes mellitus and coronary heart disease admitted to endocrinology department of the hospital from July 2022 to January 2023 were selected as research objects and randomly divided into control group and experimental group,with 50 cases in each group.The control group received basic treatment of coronary heart disease such as anticoagulation and prevention of angina pectoris,combined with metformin and simegalotide hypoglycemic treatment.The experimental group was given Jinlida Granules on the basis of the control group.The clinical efficacy,glucose and lipid metabo-lism,vascular endothelial function and cardiac function before and after intervention were observed and compared between the two groups.Results The effective rate of the control group was 80.00％(40/50),and that of the experimental group was 94.00％(47/50),which was significantly higher than that of the control group(P＜0.05).After 3 months of treatment,fasting blood glu-cose(FBG)and 2-hour postprandial blood glucose(2 hPG)and glycosylated hemoglobin(HbA1C)in the experimental group were significantly decreased compared with those in the control group(P＜0.05).There was no significant difference in blood lipid levels between the two groups before treatment(P＞0.05).After 3 months of treatment,compared with those in the control group,the levels of total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)in the experimental group were significantly decreased,while the levels of high density lipoprotein cholesterol(HDL-C)were significantly increased(P＜0.01,P＜0.05).The values of left ventricular ejection fraction(LVEF),stroke volume(SV)and left ventricular early/late diastolic peak rate ratio(E/A)were significantly increased compared with those of the control group(P＜0.01).After interven-tion,the levels of vascular endothelial growth factor(VEGF)and nitric oxide(NO)in the serum of the experimental group were significantly increased compared to those of the control group,while the levels of endothelin-1(ET-1)were significantly de-creased(P＜0.01).During the intervention process,the main adverse reactions of the two groups were rash,headache,hypo-glycemia and gastrointestinal discomfort,but there was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Jinlida Granules combined with simeglutide can significantly improve the clinical efficacy of patients with type 2 diabetes mellitus complicated with coronary heart disease,regulate the disorder of glucose and lipid metab-olism,and protect the heart and vascular endothelial function.
关键词
津力达颗粒/司美格鲁肽/2型糖尿病/冠心病/糖脂代谢/心功能/血管内皮功能/临床研究Key words
Jinlida Granules(津力达颗粒)/simaglutide/type 2 diabetes mellitus/coronary heart disease/glycolipid metabo-lism/cardiac function/vascular endothelial function/clinical research引用本文复制引用
基金项目
国家新药创新重大项目(2008ZX09101-002)
河北省卫生健康委员会医学科学研究课题计划项目(20232188)
出版年
2024
NETL
NSTL
万方数据