Clinical Effect of Jiawei Zuojin Pill(加味左金丸)on Functional Dyspepsia of Heat Stagnation in Liver and Stomach Type and Its Influence on Related Hormone Levels
Objective To observe the clinical effect of Jiawei Zuojin Pill(加味左金丸)on functional dyspepsia of heat stagna-tion in liver and stomach type and its influence on related hormone levels.Methods A total of 120 patients with functional dys-pepsia due to heat stagnation in liver and stomach(from January 2021 to January 2023)in the Spleen and Stomach Diseases De-partment of Nanjing Integrated Traditional Chinese and Western Medicine Hospital were enrolled in this study.The patients were divided into control group(60 cases)and treatment group(60 cases)by random number table method.The patients in the control group were treated with Domperidone Tablets.Those in the treatment group were given Domperidone Tablets combined with Jia-wei Zuojin Pill.The clinical treatment effect,integral changes of TCM syndrome(epigastric pain,postprandial fullness,epigastric burning sensation,belching,etc.)before and after treatment,the improvement time of epigastric pain,postprandial fullness,epi-gastric burning sensation,belching and other symptoms,the level changes of gastrin and motilin of patients before and after treat-ment,the levels of serum interleukin-6(IL-6)and tumor necrosis factor α(TNF-α),nephrology dyspepsia index(NDT),short form 36 questionnaire(SF-36),score changes and adverse reactions of two groups were observed.Results The total effec-tive rate of the treatment group was higher than that in the control group[95.00％(57/60)vs 83.33％(50/60)](P＜0.05).The improvement time of upper abdominal pain,postprandial fullness,burning sensation in the upper abdomen and belching in the treatment group was shorter than that in the control group(P＜0.05).Before treatment,the scores of TCM symptoms(upper ab-dominal pain,postprandial fullness,burning sensation in the upper abdomen,belching,etc.),the levels of gastrin,motilin,IL-6 and TNF-α,NDT and SF-36 scores not significant in both groups(P＞0.05).After treatment,the scores of TCM symptoms(upper abdominal pain,postprandial fullness,burning sensation in the upper abdomen,belching,etc.),the levels of gastrin,moti-lin,IL-6 and TNF-α,NDT and SF-36 scores were improved in both groups.And the indexes in the treatment group were all better than those in the control group after treatment(P＜0.05).There were few adverse reactions in treatment group and control group(P＞0.05).Conclusion Jiawei Zuojin Pill has significant clinical efficacy in the treatment of functional dyspepsia of heat stagnation in liver and stomach type,which can better improve the gastrointestinal function of patients,promote the recover faster and improve the quality of life of patients,with few adverse reactions.It is safe and reliable.
functional dyspepsia of heat stagnation in liver and stomach typeJiawei Zuojin Pill(加味左金丸)Domperidone Tabletsclinical effectgastrinadverse reaction
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