Clinical Curative Effect of Huoxue Huayu Tongluo Decoction(活血化瘀通络汤)on Tubal Obstructive Infertility and Its Influence on Local Pelvic Microenvironment and Ovarian Hemodynamic Parameters
Objective To evaluate the clinical efficacy of Huoxue Huayu Tongluo Decoction(活血化瘀通络汤)on tubal ob-structive infertility and its influence on local pelvic microenvironment and ovarian hemodynamic parameters.Methods A total of 104 patients with tubal obstruction infertility admitted to the hospital from October 2020 to October 2022 were selected and divid-ed into the control group and the observation group by random number table method,with 52 cases in each group.The patients in the control group were treated with tubal drainage,and Cefixime Dispersible Tablets were taken orally after the operation.The ob-servation group was given Huoxue Huayu Tongluo Decoction on the basis of the control group.Both groups were treated for 3 menstrual cycles.The treatment effect,menstrual blood cytokines,ovarian hemodynamics,inflammatory factor levels and pregnan-cy status of two groups were compared.Results After treatment,the total effective rate of the control group was 76.92％(40/52),which was significantly lower than that(92.31％,48/52)in the observation group(P＜0.05).After treatment,the levels of CXC chemokine ligand-1(CXCL1)and CXC chemokine ligand-13(CXCL13)in menstrual blood of two groups were significantly reduced compared to those before treatment(P＜0.05),and the levels of the observation group were lower than those of the con-trol group(P＜0.05).The ovarian hemodynamic parameters of the two groups were significantly improved after treatment,and the difference was statistically significant(P＜0.05).The values of peak systolic velocity(PSV)and pulse index(PI)of the ob-servation group were significantly higher than those in the control group(P＜0.05),and the value of resistance index(RI)of the observation group was significantly lower than that in the control group(P＜0.05).After treatment,the levels of inflammatory factors in the two groups were significantly lower than those before treatment(P＜0.05)and the levels of the observation group were significantly lower than those of the control group(P＜0.05).After treatment,the pregnancy rate in the control group was 40.38％(21/52),which was significantly lower than that(73.08％,38/52)in the observation group(P＜0.05).Conclusion-Huoxue Huayu Tongluo Decoction can significantly improve the clinical curative effect in the treatment of tubal obstruction,im-prove the local pelvic microenvironment and ovarian hemodynamics,reduce the levels of inflammatory factors,and finally increase the pregnancy rate of patients.
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