Study on Curative Effect of Shenqi Gujin Decoction(参芪固金汤)in Treatment of Radiation Pneumonia and Change of IL-8 and Oxygen Free Radical in Patients
Objective To study the effect of Shenqi Gujin Decoction(参芪固金汤)in the adjuvant treatment of radiation pneumonia(RP)and the changes of interleukin-8(IL-8)and oxygen free radical in patients.Methods A total of 80 RP pa-tients admitted to the hospital from April 2020 to December 2022 were selected.According to random number method,they were divided into conventional group(40 cases)and Shenqi Gujin Decoction group(40 cases).The conventional group was treated with hormone,anti-infection,relieving cough and reducing phlegm,nutritional support and other conventional treatments,while the Shenqi Gujin Decoction group was treated with Shenqi Gujin Decoction on the basis of the conventional group.The levels of lung function,oxygen free radicals and inflammatory factors were compared between the two groups.Results The total effective rate of the Shenqi Gujin Decoction group was 90.00％(36/40),higher than that of the conventional group[72.50％(29/40)],and the difference was statistically significant(P＜0.05).There was no significant difference in the indexes of pre-treatment lung function between the two groups(P＞0.05).The levels of vital capacity(VC)[(2.92±0.45)L]and carbon monoxide dis-persion(DLCO)[(18.24±3.96)mL/min]in the Shenqi Gujin Decoction group after treatment were higher than those in the conventional group(P＜0.05).There were no significant differences in the levels of interleukin-1(IL-1),IL-8,procalcito-nin(PCT),transforming growth factor-β1(TGF-β1)or oxygen free radicals between the two groups before treatment(P＞0.05).After treatment,the levels of IL-1,IL-8,PCT and TGF-β1 in the Shenqi Gujin Decoction group were lower than those in the conventional group,and other indexes were higher than those in the conventional group(P＜0.05).Conclusion Sh-enqi Gujin Decoction can reduce inflammatory reaction,eliminate oxygen free radicals and improve lung function in the treatment of radiation pneumonia.
Shenqi Gujin Decoction(参芪固金汤)radiation pneumoniainflammatory reactionoxygen free radicallung function
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