Effect of Modified Gancao Xiexin Decoction(甘草泻心汤加减)Combined with Mesalazine on Intestinal Functional Barrier and Tryptophan Metabolism in Patients with Ulcerative Colitis
Objective To investigate the effect of Modified Gancao Xiexin Decoction(甘草泻心汤加减)combined with me-salazine on the intestinal function barrier and tryptophan metabolism in patients with ulcerative colitis(UC).Methods A total of 142 UC patients in the hospital from April 2019 to April 2021 were selected and randomly divided into an observation group(71 cases)and a control group(1 cases)according to the random number table method.The patients in the control group were trea-ted with mesalazine,and those of the observation group were combined with Gancao Xiexin Decoction on the basis of the control group.The treatment course of the two groups was 12 weeks.The clinical efficacy of the two groups after 12 weeks of treatment was compared.The severity of intestinal mucosal lesions[modified Mayo score and Geboes index]and intestinal barrier function[endotoxin,diamine oxidase(DAO)and D-lactic acid]before and after 12 weeks of treatment were compared.Tryptophan me-tabolism[kynurenine(Kyn),kynurenic acid(KynA)and quinolinic acid(QuinA)]and adverse drug reactions were compared.Results The total effective rate of the observation group(91.55％,65/71)was higher than that of the control group(74.65％,53/71)(P＜0.05).After treatment of 12 weeks,the modified Mayo score and Geboes index of UC patients of the two groups were lower than those before treatment(P＜0.05).The modified Mayo score and Geboes index of the observation group were lower than those of the control group(P＜0.05).After treatment of 12 weeks,the levels of endotoxin,DAO and D-lactic acid of the two groups were lower than those before treatment(P＜0.05).The levels of endotoxin,DAO and D-lactic acid of the observa-tion group were lower than those of the control group(P＜0.05).After treatment of 12 weeks,the ratio of QuinA/Kyn of the two groups was lower than those before treatment,while the ratios of KynA/QuinA and KynA/Kyn were higher than those before treatment(P＜0.05).The ratio of QuinA/Kyn of the observation group was lower than that of the control group,while the ratios of KynA/QuinA and KynA/Kyn were higher than those of the control group(P＜0.05).After treatment of 12 weeks,the IBDQ scores of the UC patients in the two groups were significantly increased(P＜0.05).The IBDQ scores of UC patients in the obser-vation group were higher than those of the control group(P＜0.05).The two groups had no obvious adverse reactions during the treatment.Conclusion Modified Gancao Xiexin Decoction combined with mesalazine has a good effect on patients with UC,which can reduce the severity of intestinal mucosal lesions and improve the intestinal barrier function and tryptophan metabolism in pa-tients.
Modified Gancao Xiexin Decoction(甘草泻心汤加减)mesalazineulcerative colitisintestinal function barriertryptophan metabolism
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