半夏多糖的提取纯化、结构分析及药理作用研究进展
Research Progress in Extraction,Purification,Structure Analysis and Pharmacological Action of Banxia(Pinellia Rhizoma)Polysaccharide
高奎旭 1王瑶 1胡美变 1刘玉杰1
作者信息
- 1. 山西中医药大学,山西晋中 030619;中药炮制山西省重点实验室,山西晋中 030619
- 折叠
摘要
半夏为天南星科植物半夏Pinellia ternata(Thunb.)Breit.的块茎,具有燥湿化痰、降逆止呕、消痞散结的功效,而与功效相对应的物质基础尚不明确.根据半夏现代研究进展,可以得知半夏主要含有生物碱类、黄酮类、蛋白质、多糖等成分,其中多糖是半夏重要的活性成分,是其发挥功效的物质基础之一,研究却比较浅显、不够深入.对半夏多糖现代研究进展进行总结,从提取工艺优化、分离纯化及结构分析、药理作用和炮制后多糖含量变化等方面进行了综述.结果表明,目前半夏主要集中于粗多糖的提取工艺优化和抗肿瘤、抗氧化等药理作用研究,而对于半夏初始功效涉及不足.应进一步加强对半夏多糖的研究,通过分析多糖结构和确定初始功效的物质基础与生物活性,为半夏多糖及其物质基础研究提供参考.
Abstract
Banxia(Pinellia Rhizoma,PR)is the tuber of Araceae plant Banxia[Pinellia ternata(Thunb.)Breit].It has the effect of drying dampness and resolving phlegm,reducing reverse vomiting,dispersing abdominal mass and resolving accumula-tion,but the material basis of the corresponding effect is not clear.According to the modern research progress of PR,it can be known that PR mainly contains alkaloids,flavonoids,proteins,polysaccharides and other components.Among them,polysaccha-rides are important active components of PR,and they are one of the material foundations for the effectiveness of PR,but the re-search is relatively shallow and insufficient.In this paper,the research progress of PR polysaccharides was summarized from the aspects of extraction optimization,separation,purification and structure analysis,pharmacological action and changes of polysac-charide content after processing.The results show that at present,PR mainly focuses on the extraction optimization of crude poly-saccharides,and the anti-tumor,the antioxidant and other pharmacological effects.But the study of initial efficacy of PR was in-sufficient.The author believes that the study of PR polysaccharides should be further strengthened,and the material basis and bi-ological activity of initial efficacy of PR should be determined by analyzing the structure of polysaccharides,so as to provide refer-ence for the study of PR polysaccharide and its material basis.
关键词
半夏多糖/提取/分离/结构分析/含量测定/药理作用Key words
Banxia(Pinellia Rhizoma)polysaccharide/extraction/separation/structural analysis/content determination/phar-macological action引用本文复制引用
基金项目
国家自然科学基金青年科学基金项目(82104547)
山西省科技厅基础研究计划项目(20210302124278)
山西省高等学校科技创新项目(2021L358)
山西省中医药管理局科研项目(2023ZYYC059)
山西中医药大学博士科研启动基金项目(2022BK09)
山西中医药大学优秀博士毕业生来晋工作奖励经费科研启动基金项目(2022BKS06)
山西中医药大学科技创新能力培育计划"基础研究专项"(2021PY-JC-12)
山西中医药大学研究生教育改革及创新创业项目(2023CX041)
山西中医药大学研究生教育改革及创新创业项目(2023CX046)
出版年
2024
NETL
NSTL
万方数据