Research Progress on Hepatotoxicity of Buguzhi(Psoraleae Fructus)and Its Attenuation Methods
Buguzhi(Psoraleae Fructus)is a traditional non-toxic Chinese medicine commonly used in clinic because phar-macological research shows that Buguzhi(Psoraleae Fructus)is widely used in the treatment of kidney diseases,spleen and stom-ach diseases,limb meridian diseases and gynecological diseases because it contains chemical components such as coumarins,fla-vonoids and monoterpenoids and has anti-tumor,anti-oxidation,anti-bacterial and anti-inflammatory effects,estrogen level regulation,bone growth promotion and neuroprotection.However,in recent years,the National Center for ADR Monitoring has re-peatedly notified and warned the liver injury caused by related preparations of Buguzhi(Psoraleae Fructus),such as Zhuanggu Guanjie Pill(壮骨关节丸),Xianling Gubao Capsule(仙灵骨葆胶囊)and Zhikang Capsule(致康胶囊),and there are even clinical case reports of liver injury caused by single taste of Buguzhi(Psoraleae Fructus).The phenomenon of liver injury has be-come a hot and difficult point in the current industry research which has brought great challenges to the clinical safe use of Bu-guzhi(Psoraleae Fructus).Based on the lipopolysaccharide model,our research group confirmed that Buguzhi(Psoraleae Fruc-tus)has the property of specific liver injury,and mutually verified that bavachin,corylifolinin,bakuchiol and psoralidin can in-duce liver injury by regulating PI3K-AKT signaling pathway,NF-κB signaling pathway and NLRP3 signaling pathway.There-fore,this paper sorted out and summarized the relevant literatures on hepatotoxicity of Buguzhi(Psoraleae Fructus)in recent years,discussed the main toxicological mechanisms of hepatotoxicity,and summarized the significance of compatibility and pro-cessing to reduce hepatotoxicity of Buguzhi(Psoraleae Fructus)to provide data support for clinical safe medication of Buguzhi(Psoraleae Fructus).
Buguzhi(Psoraleae Fructus)hepatotoxicitymechanismcompatibility attenuationprocessing to reduce toxicity
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