Curative Effect of Guizhi Jia Longgu Muli Decoction(桂枝加龙骨牡蛎汤)Combined with Acupuncture on Malignant Cancer-Related Insomnia
Objective To explore the curative effect of Guizhi Jia Longgu Muli Decoction(桂枝加龙骨牡蛎汤)combined with acupuncture on malignant cancer-related insomnia(CRI).Methods A total of 100 patients with CRI treated in the hospital were enrolled between October 2022 and January 2023.According to random number table method,they were divided into observation group(50 cases)and control group(50 cases).The control group was treated with routine sleeping pills,while the observation group was treated with Guizhi Jia Longgu Muli Decoction and acupuncture.The clinical curative effect and adverse reactions,the changes in scores of TCM syndromes and Pittsburgh Sleep Quality Index(PSQI),the levels of neurotransmitters[5-hydroxyin-doleacetic acid(5-HIAA),5-hydroxytryptamine(5-HT)]and inflammatory factors[interleukin-4(IL-4),interleukin-6(IL-6),interleukin-1β(IL-1 β)]before and after treatment were compared between the two groups.Results After treat-ment,the total response rate of the observation group was higher than that of the control group[94.00％(47/50)vs 86.00％(43/50)],P＜0.05).After treatment,the scores of PSQI and TCM syndromes were lower in the observation group than those in the control group[(4.81±1.34)points,(5.21±1.27)points vs(6.53±1.26)points,(8.49±1.63)points](P＜0.05).After treatment,the levels of 5-HIAA,IL-4 and IL-6 were lower in the observation group than those in the control group[(18.31±4.82)ng/mL,(22.63±6.05)ng/mL,(16.78±3.22)ng/mL vs(20.74±3.06)ng/mL,(28.94±5.17)ng/mL,(19.43±4.59)ng/mL](P＜0.05).After treatment,the levels of 5-HT and IL-1 β were higher in the observation group than those in the control group[(0.58±0.11)ng/mL,(14.54±3.16)ng/mL vs(0.53±0.08)ng/mL,(11.72±2.28)ng/mL](P＜0.05).During treatment,there were no special adverse reactions in either group.Conclusion Guizhi Jia Longgu Muli Decoction combined with acupuncture has good curative effect on CRI,which can improve the sleep quality,regulate the levels of neurotrans-mitters and inflammatory factors,with certain safety.
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