Effects of Dushen Decoction(独参汤)Combined with Misoprostol on Coagulation Function and Uterine Involvement on Patients with Uterine Atonic Hemorrhage after Labor
Objective To evaluate the effect of Dushen Decoction(独参汤)combined with misoprostol on coagulation function and uterine involution in patients with uterine atonic hemorrhage after labor.Methods A total of 96 patients with postpartum uter-ine atonic bleeding admitted to the hospital from April 2019 to April 2022 were selected as the research objects.According to the random number table method,the patients were divided into the study group and the reference group,with 48 cases in each group.The patients in the reference group were treated with conventional therapy and their vital signs,including changes in blood pres-sure,respiration,heart rate and heart rate,were closely monitored.The amount of blood loss was detected and the appropriate preparations were made in advance.The uterus can be given massage to help to stop bleeding.Intramuscular injection of tenotropin was given every 12 h at a dose of 10 U,and 400 of misoprostol was placed into the anus of the puerpera.On the basis of the treatment of the reference group,the patients in the study group were treated with Danshen Decoction orally.30 g raw sun-dried ginseng and 1000 mL distilled water were decocted to 150 mL.After the fetus was delivered,30 mL was taken orally once every 8 h.The blood loss at 24 h,48 h and 72 h after delivery was compared between the two groups.Collection method:After the amniotic fluid was drained,the urine pad and suction bottle were replaced and calculated by weighing method.Venous blood samples were collected before production and 24 h after treatment.Prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB)and thrombin time(TT)were detected by coagulation analyzer.After 1 month of postpartum follow-up,the incidence of intrauterine hemorrhage,the incidence of adverse uterine involution,the duration of lochia and the height of fundus were compared between the two groups,and the therapeutic effect was compared.Results In the study group,21 cases(43.75％)reached the effective standard,23 cases(47.92％)reached the effective standard and 4 cases(8.33％)were inef-fective.The total effective rate was 91.67％(44/48).In the reference group,17 cases(35.42％)reached the effective stand-ard,20 cases(41.67％)reached the effective standard and 11 cases(22.92％)were ineffective.The comparison between groups showed significance(x2=3.872,P=0.049).The blood loss at 24 h,48 h and 72 h after delivery in the study group was lower than that in the reference group(P＜0.05).After treatment,the levels of PT,APTT and TT in the two groups were lower than those before treatment,and the levels of FIB were higher than those before treatment.After treatment,the levels of PT,APTT and TT in the study group were higher than those in the reference group,and the level of FIB was lower than that in the reference group(P＜0.05).The incidence of intrauterine hemorrhage and adverse uterine involution in the study group were lower than those in the reference group,and the duration of lochia was lower than that in the reference group(P＜0.05).There was no sig-nificant difference in fundus height between the two groups(P＞0.05).Conclusion Dushen Decoction combined with misoprostol can improve the clinical symptoms of patients with uterine attrition hemorrhage,reduce the amount of blood loss,improve the coag-ulation related indicators,shorten the duration of lochia,reduce the incidence of uterine hemorrhage and promote the uterine invo-lution,which has good clinical application value.
Dushen Decoction(独参汤)misoprostoluterine atonic hemorrhage after deliverycoagulation functioninvolu-tion of uterusintrauterine hemorrhageresearch
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