Clinical Study on Jianpi Sanjie Decoction(健脾散结方)Combined with Drug-Loaded Microsphere Embolization in Treatment of Advanced Liver Cancer
Objective To observe the clinical effect of Jianpi Sanjie Decoction(健脾散结方)combined with drug-loaded mi-crosphere embolization in the treatment of advanced liver cancer.Methods Sixty patients with advanced liver cancer who were hospitalized in the hospital from August 2021 to December 2022 were divided into two groups according to the random number ta-ble method.Thirty patients in the control group were treated with drug-loaded microsphere embolization,and the other 30 pa-tients in the observation group were treated with Jianpi Sanjie Decoction combined with drug-loaded microsphere embolization.The objective efficacy of solid tumors,symptom improvement rate,weight change and Karnovsky health status scale(KPS)score,the changes of tumor markers alpha-fetoprotein(AFP),carbohydrate antigen 199(CA199)and carbohydrate antigen 125(CA125)and adverse reactions were compared between the two groups.Results The effective rates of the observation group and the control group were 83.33％(25/30)and 66.67％(22/30),and the difference was not statistically significant(P＞0.05).The stability rates of the observation group and the control group were 96.67％(29/30)and 73.33％(27/30),respectively.The rate of the observation group was significantly higher than that of the control group(P＜0.05).The symptom improvement rates of the observation group and the control group were 93.33％(28/30)and 70.00％(21/30),respectively.The symptom im-provement rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in weight change between the observation group and the control group(P＞0.05).After treatment,the KPS scores of the two groups were significantly increased(P＜0.05),and the score of the ob-servation group was significantly higher than that of the control group[(71.31±9.22)points vs(64.54±7.26)points](P＜0.05).The levels of tumor markers AFP,CA199 and CA125 in the observation group were significantly lower than those in the control group[(29.72±6.34)µg/L,(34.08±3.10)U/mL,(127.71±29.65)kU/L vs(34.08±5.26)µg/L,(37.67±4.35)U/mL,(156.83±27.54)kU/L](P＜0.05).The incidence of adverse reactions in the observation group was better than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Jianpi Sanjie Decoction combined with drug-loaded microsphere embolization in the treatment of advanced liver cancer can better inhibit the growth of tumor lesions,improve the clinical symptoms and the curative effect,and has good safety.It provides feasible ideas,methods and guidance for the treatment of advanced liver cancer with integrated traditional Chinese and Western medicine.
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