Observation on Clinical Effect of Yishen Tongluo Formula(益肾通络方)in Treatment of Oligoasthenozoospermia Infertility with Kidney Deficiency and Collateral Obstruction
Objective To investigate the efficacy and safety of Yishen Tongluo Formula(益肾通络方)in the treatment of oli-goasthenozoospermia infertility with kidney deficiency and collateral obstruction.Methods A total of 108 oligoasthenozoospermia infertility patients with kidney deficiency and collateral obstruction were enrolled from January 2022 to December 2022 in the Re-productive Medicine Department of Henan Province Hospital of Traditional Chinese Medicine(The Second Affiliated Hospital of Henan University of Chinese Medicine).They were randomly divided into experimental group and control group,with 54 cases in each group.The patients in the experimental group were given Yishen Tongluo Formula,one dose per day,200 mL per time,tak-ing in the morning and evening.Those in the control group were given oral levocarnitine solution,10 mL for each time,twice a day,orally with meals.Both groups were treated for 90 days,and were followed up before treatment,30,60 and 90 days and 3 months after the end of treatment.The sperm concentration,total sperm count,the percentage of progressive motility(PR),the percentage of PR+non-progressive motility(NP),and the pregnancy rates were used as the main efficacy indicators,and the se-men volume and TCM syndrome scores were used as the secondary efficacy indicators.The clinical efficacy and the improvement of symptoms before and after treatment were compared between the two groups,and the adverse reactions were observed and recor-ded.Results For intra-group comparison,compared with those before treatment,the sperm concentration,total sperm count,per-centage of sperm in PR and percentage of sperm in PR+NP were significantly improved after the treatment in both groups(P＜0.001).After treatment,compared with those of the control group,the sperm concentration,total sperm count,percentage of PR sperm and percentage of PR+NP sperm in the experimental group were significantly higher than those in the control group(P＜0.001).However,there was no significant difference in the pregnancy rate of spouses between the two groups(P＞0.05).For intra-group comparison,compared with those before treatment,only the semen volume increased and the total score of TCM syn-drome decreased in the experimental group(P＜0.05).There was no significant difference in semen volume between the two groups(P＞0.05),but comparison between groups at the same period showed the experimental group was better than the control group in reducing the total score of TCM syndromes at each visit(P＜0.01).Especially in the improvement of waist and knee soreness and weakness,stabbing pain in lower abdomen,groin or perineal tingling,dizziness,tinnitus,fatigue,dark tongue color,pehiae or ecchymosis of the tongue,slow and deep pulse or unsmooth pulse,the group differences were statistically significant(P＜0.05).After the study,the total effective rates of the experimental group and the control group were 88.00％(44/50)and 66.67％(34/51),respectively,and the difference between the two groups was statistically significant(P＜0.05).There were no obvious adverse reactions in the two groups during the study.Conclusion Yishen Tongluo Formula in the treatment of oligoasthe-nozoospermia infertility patients with kidney deficiency and collateral obstruction is effective and safe,which is worthy of clinical promotion and application.
Yishen Tongluo Formula(益肾通络方)oligoasthenozoospermiakidney deficiency and collateral obstructionmale infertility
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