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大黄?虫丸临床应用及实验研究进展

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大黄䗪虫丸为张仲景治疗虚劳干血的有效方剂。该方是在抵挡汤的基础上加苦杏仁、黄芩、地黄、白芍等8味中药组成,具有活血破瘀、缓中补虚之功,即峻药丸服,以缓攻瘀血,瘀血去则新血生,最终达扶正不留瘀、祛瘀不伤正的目的。适用于虚劳后期、因虚致瘀之证,故此方兼具扶正与祛邪双重功效。临床运用方面,单用大黄䗪虫丸治疗相关疾病的报道偏少,多以其加减方或联合其他方剂或联合西药,治疗肝、心、肺、肾、妇科、男科等各类疾病。实验研究方面,大黄䗪虫丸具有抗炎、抗纤维化,改善血糖、改善血脂、改善血管功能,改善微循环等作用,多针对某一具体疾病探讨其作用、机制,故其物质基础研究相对薄弱。通过查阅近10年大黄䗪虫丸临床应用及实验研究情况,对其临床应用及实验研究进展进行归纳总结,为大黄䗪虫丸深入研究、运用提供参考。
Clinical Application and Experimental Research Progress of Dahuang Zhechong Pill(大黄?虫丸)
Dahuang Zhechong Pill(大黄䗪虫丸)is an effective prescription of ZHANG Zhongjing for treating asthenia and dried blood.The prescription is composed of 8 kinds of Chinese herbs,such as Kuxingren(Armeniacae Semen Amarum),Huan-gqin(Scutellariae Radix),Dihuang(Rehmanniae Radix)and Baishao(Paeoniae Radix Alba)based on Didang Decoction(抵挡汤).It has the function of promoting blood circulation,breaking blood stasis,soothing the middle and tonifying deficiency,that is,taking the drug with strong efficacy with pills to slow down the attack on blood stasis.When blood stasis is eliminated,new blood will be generated,ultimately achieving the goal of supporting the right Qi without leaving blood stasis,and removing blood stasis without damaging the right Qi.This formula is suitable for the late stage of deficiency and fatigue,as it can treat the defi-ciency syndrome due to blood stasis due.Therefore,it has a dual effect of nourishing the body and eliminating evil spirits.In the aspect of clinical application,there are few reports on the treatment of related diseases with Dahuang Zhechong Pill alone,and most of them are added or subtracted,or combined with other prescriptions or Western medicine,treating liver,heart,lung,kid-ney,gynecology,andrology and other diseases.In the experimental research,Dahuang Zhechong Pill has the effects of anti-in-flammation,anti-fibrosis,improving blood sugar,improving blood lipid,improving blood vessel function,improving microcircula-tion and so on.Therefore,its material basis research is relatively weak.In this paper,the clinical application and experimental research of Dahuang Zhuchong Pill in recent ten years were reviewed and summarized,which provided reference for further re-search and application of Dahuang Zhuchong Pill.

Dahuang Zhechong Pillclinical applicationexperimental researchprogress

荣宝山、石志强、翟佳滨

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内蒙古医科大学,内蒙古呼和浩特 010011

大黄䗪虫丸证 临床应用 实验研究 进展

国家自然科学基金项目内蒙古自然科学基金项目内蒙古卫生健康委员会项目内蒙古卫生健康委员会项目内蒙古科技计划项目

816607922020LH080332022021332022021392019GG079

2024

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子:1.007
ISSN:1673-7717
年,卷(期):2024.42(8)