Study on Improvement of Symptoms and Antioxidant Mechanisms in Gastric Cancer Patients with Combination of Fuzheng Guben Formula(扶正固本方)and Acupuncture
Objective To analyze the clinical efficacy of Fuzheng Guben Formula(扶正固本方)combined with acupuncture in the treatment of gastric cancer and its influence on oxidative stress.Methods Ninety-four patients with gastric cancer admitted to the hospital from September 2022 to June 2023 were included as research objects.They were randomly divided into two groups.Forty-seven patients in the control group received chemotherapy treatment and 47 patients in the observation group received Fuzheng Guben Formula combined acupuncture treatment on this basis.The difference of curative effect,inflammatory factor lev-el,oxidative stress level and T cell subgroup index level were compared between the two groups.Results The objective remission rate and disease control rate of the observation group were 40.43％(19/47)and 93.62％(44/47),respectively,which were higher than 25.53％(12/47)and 76.60％(36/47)in the control group(P＜0.05).The levels of glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD)in observation group were higher than those in control group,and the levels of ma-londialdehyde(MDA)and reactive oxygen species(ROS)were lower than those in control group(P＜0.05).The levels of inter-feron gamma-γ(IFN-γ)and tumor necrosis factor-α(TNF-α)in the observation group were higher than those in the con-trol group,the levels of interleukin-6(IL-6)and interleukin-8(IL-8)were lower than those in the control group,the values of CD3+and CD4+/CD8+were higher than those in the control group,and the value of CD4+was lower than that in the control group(P＜0.05).Conclusion Fuzheng Guben Formula combined acupuncture has a clear effect on gastric cancer patients,which is conducive to reducing the inflammatory stimulus response,improving the level of oxidative stress and the immune function of pa-tients,regulating the immune imbalance,and improving the prognosis of patients.
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