Clinical Efficacy of Qingfei Huatan and Jiangni Pingchuan Prescription(清肺化痰、降逆平喘方)in Treatment of AECOPD and Its Influence on Peripheral Blood PCT,CRP,IL-6 and Immune Function
Objective To observe the clinical efficacy of Qingfei Huatan and Jiangni Pingchuan Prescription(清肺化痰、降逆平喘方)combined with conventional Western medicine in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and to analyze the mechanism of action and its effect on procalcitonin(PCT),C-reactive protein(CRP),in-terleukin-6(IL-6)and immune function in peripheral blood of patients.Methods A total of 80 patients with AECOPD admit-ted to the respiratory Department of Hebei Hospital of Traditional Chinese Medicine from June 2021 to June 2022 were selected according to the inclusion criteria and exclusion criteria.According to the voluntary principle,the above patients were divided into the control group(40 cases)and the experimental group(40 cases).On the basis of conventional western medicine treatment,the treatment of Qingfei Huatan and Jiangni Pingchuan Prescription was given.The clinical efficacy,lung function,immune function,quality of life and serum inflammation levels before and after intervention were compared between the two groups,and the inci-dence of adverse reactions was observed.Results The total effective rate of the control group was 80.00％,and that of the experi-mental group was 95.00％.Compared with that of the control group,the total effective rate of the experimental group was signifi-cantly increased(P＜0.05).After 2 weeks of intervention,the values of first second forced expiratory volume(FEV1),forced vi-tal capacity(FVC)and the ratio of FEV1/FVC of the experimental group were significantly higher than those of the control group(P＜0.01).Before treatment,there were no significant differences in St.George's Respiratory Questionnaire(SGRQ)score,modified Medical Research Council(mMRC)or COPD Assessment Test(CAT)score between the two groups(P＞0.05).After 2 weeks of intervention,the SGRQ score,mMRC and CAT score of the experimental group were significantly lower than those of the control group(P＜0.01).Compared with those of the control group,the levels of IL-6,CRP and PCT in the experimental group were significantly decreased(P＜0.01).After intervention,the levels of CD3+,CD4+and CD4+/CD8+in the experimental group were significantly higher than those in the control group,while the levels of CD8+were significantly lower than those in the control group(P＜0.01).Compared with those of the control group,there was no significant difference in the incidence of nause-a,palpitation,dyspnea,rash and other adverse reactions in the experimental group(P＞0.05).Conclusion Qingfei Huatan and Jiangni Pingchuan Prescription combined with conventional Western medicine in the treatment of AECOPD can improve the cura-tive effect and the lung function of patients,and regulate the inflammatory response and immune function of the body,so as to im-prove the quality of life of patients.
Qingfei Huatan and Jiangni Pingchuan Prescription(清肺化痰、降逆平喘方)AECOPDclinical efficacyin-flammatory factorsimmune functionmechanism
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