Effects of Suanwei Formula(酸味方)on Levels of AFP,CEA,CA-125 and CD4+/CD8+in Serum after TACE Operation for Primary Liver Cancer
Objective To observe the effects of Suanwei Formula(酸味方)on the levels of alpha-fetoprotein(AFP),carcino-embryonic antigen(CEA),carbohydrate antigen-125(CA-125)and CD4+/CD8+in serum after transcatheter arterial chemoem-bolization(TACE)for primary liver cancer.Methods A total of 82 patients with primary liver cancer admitted to the hospital from August 2019 to November 2022 were included and divided into observation group(41 cases)and control group(41 cases)by sim-ple random sampling method.The control group was treated with TACE and received symptomatic support such as nutritional sup-port,anti-infection and liver protection after surgery.The observation group was treated with Suanwei Formula for 4 weeks on the basis of the control group.The disease control rate,TCM syndrome score before and after treatment and the scores of liver cancer patients'post-life quality measurement scale(QOL-LC)were compared between the two groups.The levels of AFP,CEA and CA-125 in serum were detected before and after treatment.The proportions of CD4+,CD8+and natural killer(NK)cells in T lymphocyte subsets of peripheral blood were detected before and after treatment,and CD4+/CD8+was calculated.The occur-rence of adverse reactions was recorded.Results The disease control rates of the two groups were 92.68％(38/41)and 75.61％(31/41),respectively,and the disease control rate of the observation group was higher(P＜0.05).TCM syndrome scores of the two groups after treatment were lower than those before treatment,and the score of the observation group was lower than that of the control group(P＜0.05).After treatment,the levels of AFP,CEA and CA-125 in the observation group were(62.35±9.12)ng/mL,(2.13±0.39)μg/mL and(32.37±5.93)U/mL,respectively.The levels of AFP,CEA and CA-125 in the control group were(139.65±20.71)ng/mL,(2.47±0.42)μg/mL and(49.62±6.03)U/mL,respectively.The levels of AFP,CEA and CA-125 in the observation group were lower than those in the control group(P＜0.05).The levels of CD4+,CD8+,CD4+/CD8+and NK cells in the observation group after treatment were 44.08％±5.41％,21.64％±2.96％,1.65％±0.28％and 35.42％±3.97％,respectively.After treatment,the levels of CD4+,CD8+,CD4+/CD8+and NK cells in the control group were 37.26％±4.76％,25.47％±3.08％,1.22％±0.27％and 29.65％±4.25％,respectively.The levels of CD4+,CD4+/CD8+and NK cells in the observation group were higher than those in the control group.CD8+cell level was lower than that of the con-trol group(P＜0.05).The physical function and symptom scores of the two groups were improved after treatment,and those of the observation group were higher than those of the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The application of Suanwei Formula after TACE surgery for primary liver cancer is beneficial to improve the disease control rate,reduce the TCM syndrome scores,inhibit the levels of serum tumor markers,improve the CD4+/CD8+ratio and the QOL-LC score,and has good safety and popularization value.
NETL
NSTL
万方数据
