Clinical Observation on Ankylosing Spondylitis Treated by Shenshi Qianghuo Dihuang Decoction(沈氏羌活地黄汤)
Objective To observe the clinical efficacy and safety of Shenshi Qianghuo Dihuang Decoction(沈氏羌活地黄汤)in the treatment of ankylosing spondylitis.Methods In this study,90 patients with ankylosing spondylitis were divided into treat-ment group and control group,45 cases in each group.The control group received methotrexate tablets,15 mg for each time,once a week.The treatment group was combined with Shenshi Qianghuo Dihuang Decoction orally on the basis of the control group,200 mL for each time,twice a day.The course of treatment was 12 weeks.Results The total effective rate of the treatment group was 91％(41/45),and ASAS20 scores accounted for 93％(42/45)of the total number of patients in the treatment group.The total effective rate of the control group was 53％(24/45),and the ASAS20 scoring standard accounted for 67％(30/45).The curative effect of the treatment group was better than that of the control group(P＜0.05).Bath ankylosing spondylitis disease ac-tivity index(BASDAI)scores were significantly improved in both groups(P＜0.01),and the BASDAI score of the treatment group was significantly better than that of the control group(P＜0.01).Bath andylosing spondylitis function index(BASFI)score in the treatment group was significantly improved(P＜0.01)and significantly better than that in the control group(P＜0.01).After treatment,inflammatory activity indexes,C-reactive protein(CRP)and overall assessment(PGA)were significantly im-proved in two groups(P＜0.01),and there was no difference between groups.The improvement of erythrocyte sedimentation rate(ESR)in the treatment group was significant(P＜0.01),which was significantly better than that in control group(P＜0.05).Con-clusion The effect of combined treatment with methotrexate on ankylosing spondylitis is better than that of single treatment with methotrexate without adverse reactions.
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