首页|铁死亡干预结直肠癌细胞耐药的中西医研究进展

铁死亡干预结直肠癌细胞耐药的中西医研究进展

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耐药是结直肠癌(colorectal cancer，CRC)晚期治疗的难点，而铁死亡(ferroptosis)作为一种不同于凋亡、坏死、自噬等传统途径的新兴死亡形式，能通过脂质过氧化的方式绕过CRC的耐药环节，进而诱导细胞死亡，为克服CRC耐药提供了新的干预靶点及治疗思路。详细论述铁死亡及CRC耐药的机制，探索相关干预靶点，从铁死亡干预化疗耐药、靶向耐药、免疫耐药等角度出发，总结近年来有关铁死亡干预CRC耐药细胞的研究进展，并概述了我国传统中药提取物诱导耐药CRC细胞铁死亡的近期研究，为后续更进一步的机制探索及临床研究打下基础。
Research Progress of Traditional Chinese and Western Medicine on Ferroptosis Overcome Drug Resistance of Colorectal Cancer
In the realm of colorectal cancer treatment,drug resistance is a formidable obstacle.Ferroptosis is a recently dis-covered mechanism of cell death that differs from necrosis,autophagy,apoptosis and other traditional pathways.It may trigger cell death through lipid peroxidation,which circumvents the drug resistance link in colorectal cancer(CRC)and provides a novel tar-get for intervention and therapeutic ideas to overcome drug resistance in CRC.This paper presented a comprehensive overview of the mechanisms underlying ferroptosis and CRC drug resistance,including relevant intervention targets and a summary of the latest advances in ferroptosis intervention research on drug-resistant CRC cells from the perspectives of ferroptosis intervention on im-mune,targeted and chemotherapeutic resistance.In addition,the relevant mechanisms of traditional Chinese medicine extracts in-tervening in drug-resistant colorectal cancer through ferroptosis were also summarized.This paper listed and summarized the tar-gets,pathways and processes of ferroptosis to overcome CRC drug resistance,laying the groundwork for more complex mechanisms and future clinical investigations.

ferroptosisdrug resistancecolorectal cancer(CRC)treatment strategiesglutathione peroxidase 4(CDX4)System Xc-reactive oxygen species(ROS)

袁见、孟丹、仇奕文、俞洋、朱莹杰

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上海中医药大学附属龙华医院,上海 200032

铁死亡 耐药 结直肠癌 治疗策略 谷胱甘肽过氧化物酶4 半胱氨酸/谷氨酸抗转运系统 脂质活性氧

国家自然科学基金青年科学基金项目上海市临床重点专科建设项目

81703907SHSLCZDZK03701

2024

10.13193/j.issn.1673-7717.2024.08.031

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子：1.007
ISSN：1673-7717
年,卷(期)：2024.42(8)