Research Progress in Application of Tetramethylpyrazine and Related Preparations in Cerebrovascular Diseases
With the increasing incidence of cerebrovascular diseases,Chinese medicines for promoting blood circulation and removing blood stasis have increasingly become research hotspots in protecting cerebrovascular diseases.Tetramethylpyrazine is a pyrazine active ingredient extracted from Chuanxiong(Chuanxiong Rhizoma),which has many functions such as anti-inflamma-tion,immunoregulation and vasodilation.A large number of in vitro and in vivo studies have confirmed that ligustrazine can pro-tect vascular endothelial cells,neurons,anti-inflammation,anti-oxidation and anti-platelet aggregation.In this paper,the cer-ebral vascular protective effect and its mechanism of ligustrazine were reviewed,and the current combined use of ligustrazine was analyzed,so as to better clarify the therapeutic approach and mechanism of ligustrazine,and further promote the development of li-gustrazine research and better clinical application.
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