中药调节下丘脑-垂体-卵巢轴干预围绝经期抑郁症的研究进展
Research Progress of Chinese medicine Regulating Hypothalamic Pituitary Ovarian Axis to Intervene Perimenopausal Depression
常卓 1朱慧 1周雪明 1姜北 1孙延平 1邓贺 1尹雅静 1梁碧月 1潘雪 2匡海学1
作者信息
- 1. 黑龙江中医药大学,黑龙江哈尔滨 151000
- 2. 中国中医科学院博士后科研流动站,北京 100700
- 折叠
摘要
围绝经期抑郁症(perimenopausal depressive disorder,PDD)是一种围绝经期女性高发的情绪障碍类疾病,严重威胁患病女性的生理、心理健康.PDD的发病机制与激素水平波动、单胺类神经递质减少、下丘脑-垂体-肾上腺轴(hypothalamic pituitary adrenal axis,HPA)失调、下丘脑-垂体-卵巢轴(hypothalamic pituitary ovarian axis,HPO)失衡、γ-氨基丁酸(gamma-aminobutyric acid,GAB A)系统失调等相关.其中,HPO失衡似乎更与PDD特殊的性别、发病时期关系密切,故也成了研究的热点.抑郁症一直是中医治疗的优势病种,特别是在中医理论指导下的中药治疗对于PDD的防治研究也具有丰富的理论基础与研究成果.通过对近5年的文献整理,围绕HPO轴在PDD中的作用,中医药调节HPO轴干预PDD的理论基础,中药复方、单味中药及中药单体化合物通过调节HPO轴治疗PDD的研究进展进行了综合性叙述.
Abstract
Perimenopausal depressive disorder(PDD)is an emotional disorder that is highly prevalent in perimenopausal women,and is a significant threat to their physical and mental well-being.The pathogenesis of PDD is associated with hormonal fluctuations,decreased levels of monoamine neurotransmitters,imbalance of the hypothalamic-pituitary-adrenal(HPA)axis,imbalance of the hypothalamic-pituitary-ovarian(HPO)axis,imbalance of the gamma-aminobutyric acid(GABA)system and other factors.The imbalance of the HPO axis is particularly relevant to the gender-specific and pathogenic nature of PDD and has become a research focus.Depression has always been a dominant disease of TCM treatment,and TCM treatment has a strong theoretical basis and research findings for the prevention and treatment of PDD,particularly under TCM theory guidance.This ar-ticle summarized the literature of the past five years,focusing on the role of the HPO axis in PDD,the theoretical basis of TCM regulating the HPO axis and intervening in PDD,and a comprehensive description of the research progress of TCM formulae,sin-gle Chinese medicine and single Chinese medicine monomer compounds in treating PDD by regulating the HPO axis.
关键词
中药/下丘脑-垂体-卵巢轴/围绝经期抑郁症Key words
Chinese medicine/HPO/PDD引用本文复制引用
基金项目
国家中医药管理局中医药传承与创新"百千万"人才工程—岐黄工程首席科学家支持项目(国中医药人教函[2021]7号)
国家中医药管理局中医药传承与创新"百千万"人才工程(岐黄工程)岐黄学者支持项目(国中医药人教函[2018]284号)
黑龙江省中医药管理局科研项目(ZHY2022-110)
黑龙江中医药大学优秀青年教师支持计划(2018RCQ05)
出版年
2024
NETL
NSTL
万方数据