Research Progress of Chinese medicine Regulating Hypothalamic Pituitary Ovarian Axis to Intervene Perimenopausal Depression
Perimenopausal depressive disorder(PDD)is an emotional disorder that is highly prevalent in perimenopausal women,and is a significant threat to their physical and mental well-being.The pathogenesis of PDD is associated with hormonal fluctuations,decreased levels of monoamine neurotransmitters,imbalance of the hypothalamic-pituitary-adrenal(HPA)axis,imbalance of the hypothalamic-pituitary-ovarian(HPO)axis,imbalance of the gamma-aminobutyric acid(GABA)system and other factors.The imbalance of the HPO axis is particularly relevant to the gender-specific and pathogenic nature of PDD and has become a research focus.Depression has always been a dominant disease of TCM treatment,and TCM treatment has a strong theoretical basis and research findings for the prevention and treatment of PDD,particularly under TCM theory guidance.This ar-ticle summarized the literature of the past five years,focusing on the role of the HPO axis in PDD,the theoretical basis of TCM regulating the HPO axis and intervening in PDD,and a comprehensive description of the research progress of TCM formulae,sin-gle Chinese medicine and single Chinese medicine monomer compounds in treating PDD by regulating the HPO axis.
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