Effect of Mingmu Dihuang Decoction(明目地黄汤)on OCTA and Visual Acuity in Patients with Age-related Macular Degeneration of Liver-Kidney Deficiency Syndrome
Objective To explore the effect of Mingmu Dihuang Decoction(明目地黄汤)on optical coherence tomography an-giography(OCTA)and visual acuity in patients with age-related macular degeneration(AMD)of liver-kidney deficiency syn-drome.Methods Ninety-four patients with age-related macular degeneration in the hospital from August 2020 to August 2022 were classified into two groups by random number table methods,each with 47 cases.The control group received conbercept ther-apy.Based on this,the observation group received Mingmu Dihuang decoction combined with conbercept therapy.All patients re-ceived OCTA examination,and the parameters including macular retinal thickness and vessel densities in the foveal and parafoveal regions,corneal neovascularization(CNV),intraocular pressure,minimum resolution angle in logarithmic(logMAR),best correc-ted vision acuity(BCVA),vascular endothelial growth factor(VEGF)and C-reactive protein(CRP).Then the clinical efficacy and complication rate were compared between two groups.Results The values of CNV,macular retinal thickness and vessel densi-ties in the foveal and parafoveal regions yielded no statistical difference between two groups before treatment(P＞0.05).After treatment,no statistical difference was found in macular retinal thickness in the foveal area between two groups(P＞0.05),while the statistical difference was found in CNV,macular retinal thickness in parafoveal regions,and vessel densities in the foveal and parafoveal regions(P＜0.05).The pre-treatment intraocular pressure and logMAR showed no statistical difference between two groups(P＞0.05).After treatment,the intraocular pressure of two groups had no statistical difference,while LogMAR of the ob-servation group was notably lower than that of the control group(P＜0.05).The serum levels of VEGF and CRP demonstrated no statistical difference between two groups before treatment(P＞0.05),while the two indicators of the observation group were sig-nificantly lower than those of the control group after treatment(P＜0.05).The total efficacy rate was 91.49％(43/47)in the observation group,which was higher than 74.47％(35/47)in the control group(x2=4.821,P=0.028).The complication rate was 14.89％(7/47)in the observation group,which was slightly higher than 8.52％(4/47)in the control group,with no statisti-cal difference(x2=0.927,P=0.336).Conclusion The application of Mingmu Dihuang Decoction in patients with age-related macular degeneration of liver-kidney deficiency syndrome can effectively attenuate the inflammation response,improve the fun-dus hemorrhage and neovascular fundus condition,promote the visual recovery and improve the OCTA parameters.
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