Study on Modulating Effect and Mechanism of Chaiqi Ningshen Anmian Decoction(柴芪宁神安眠汤)Combined with Estradiol Tablets on Sleep Structure of Chronic Insomnia Patients with Deficiency of Both Heart and Spleen
Objective To investigate the modulating effect and mechanism study of Chaiqi Ningshen Anmian Decoction(柴芪宁神安眠汤)combined with Estradiol Tablets on the sleep structure of chronic insomnia patients with heart and spleen deficien-cy evidence.Methods One hundred and thirty-two patients with chronic insomnia due to deficiency of both heart and spleen in the hospital from November 2019 to November 2021 were divided into two groups.The control group(66 cases)was treated with estradiol tablets,and the treatment group(66 cases)was treated with Estradiol Tablets combined with Chaiqi Ningshen Anmian Decoction.The two groups were treated continuously for 8 weeks.Observation Indexes included pittsburgh sleep quality index(PSQ)score,sleep structure-related indexes,glycated albumin(GA),serotonin(5-HT)and clinical symptom changes.Re-sults The therapeutic efficacy of the treatment group was better than that of the control group(P＜0.05).After treatment,the scores of insomnia,dreaminess and wakefulness,less food and dullness,fatigue,palpitation,pale face,pale tongue and weak pulse were lower in the treatment group than those in the control group(P＜0.05).After treatment,PSQI score,montreal cognitive as-sessment(MoC A)score and hamilton anxiey scale(HAMA)score were lower in two groups than those before treatment,and after treatment,PSQI score,MoCA score and HAMA score were lower in the treatment group than those in the control group(P＜0.05).The total sleep time(TST),sleep efficiency(SE),N3 and rapid eye movement(REM)indexes were higher in two groups than those before treatment,and the increase was better in the treatment group than that in the control group.Sleep onset latency(SOL),wake after sleep onset(WASO),N1 and N2 indexes were lower in the treatment group than those in the control group af-ter treatment(P＜0.05).The levels of serum GA and 5-HT were higher in the treatment group than those in the control group after treatment(P＜0.05).The levels of serum interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)were lower in the treatment group than those pre-treatment and those of the control group after treatment(P＜0.05).Conclusion Chaiqi Ningshen Anmian Decoction combined with Estradiol Tablets can significantly improve the clinical symptoms,sleep quality and sleep structure in patients with chronic insomnia,and the mechanism may be related to the regulation of the levels of serum GA and 5-HT and the inhibition of central nervous excitability.
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