Effect of Modified Tongqiao Huoxue Decoction(通窍活血汤化裁)on Hcy,Lipoprotein a and Prognosis after Intravenous Thrombolysis in Acute Cerebral Infarction
Objective To observe the effect of Modified Tongqiao Huoxue Decoction(通窍活血汤化裁)on high homocysteine(Hey),lipoprotein a[LP(a)]and prognosis of acute cerebral infarction after intravenous thrombolysis.Methods A total of 120 patients with acute cerebral infarction(admitted from June 2022 to June 2023)were included and divided into the thrombolysis group(60 cases)and the traditional Chinese medicine group(60 cases)by random number table method.All patients in the thrombolytic group received alteplase thrombolytic therapy,while those in the traditional Chinese medicine group were treated with Modified Tongqiao Huoxue Decoction on the basis of thrombolytic therapy.The efficacy,changes in TCM symptom scores(hemi-plegia,mouth and eye distortion,head stabbing pain,weakness),the levels of Hcy and LP(a),the levels of serum hypersensitive C-reactive protein(hs-CRP)and interleukin-6(IL-6),the hemorheological parameters such as erythrocyte aggregation in-dex(EAI)and erythrocyte sedimentation rate(ESR),erythrocyte specific volume(HCT)and plasma viscosity(PV),National In-stitute of Health stroke scale(N1HSS)and Barthel index(BI),Stroke Patient Quality of Life Scale(QOLISP)score changes be-fore and after treatment of two groups were observed.Results The total effective rate of the traditional Chinese medicine group was significantly higher than that of the thrombolysis group(P＜0.05).Before treatment,TCM syndrome scores(hemiplegia,mouth and eye distortion,head stabbing pain,weakness),the levels of Hcy and LP(a),the levels of hs-CRP and IL-6,the values of hemorheological parameters(EAI,ESR,HCT,PV),the scores of NIHSS,BI and QOLISP were not significant in both groups(P＞0.05).After treatment,these indexes were improved in both groups.After treatment,the above indexes in the traditional Chinese medicine group were significantly better than those in the thrombolytic group(P＜0.05).Conclusion Tongqiao Huoxue Decoction can reduce the levels of Hcy and LP(a),alleviate the symptoms,improve the neurological function and the quality of life of pa-tients with acute cerebral infarction,and is worthy of application.
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