Research Progress on Toxicity and Toxicokinetics of Chinese Drugs of Aconitum
Chinese drugs,including Caowu(Radix Aconiti Kusnezoffii),Chuanwu(Radix Aconiti)and Fuzi(Radix Aconiti Lateralis),have long been used for treating diseases or as a starting point for developing and designing some new drugs because of the unique pharmacological effects and remarkable pharmacological activity.Therefore,Chinese drugs of Aconitum is widely used and has certain research value.Although Chinese drugs of Aconitum have obvious curative effect and irreplaceable curative effect,the toxic effect can not be ignored,and its clinical use worries doctors and patients.Therefore,people have been working hard for a long time to study the methods and means of safe use of Aconitum,and to explore the unique pharmacological activities of Aconitum,and at the same time,people are deeply studying the means to prevent Aconitum poisoning.The study of toxicokinet-ics is an important means to evaluate the efficacy,toxicity,drug safety and poisoning inference of drugs,and it is also one of the methods to explain the experimental results of drug exposure toxicity and predict the adverse reactions of human drug.Therefore,the research methods of toxicity and toxicokinetics of Aconitum were summarized in this paper,in order to provide reference for the study of synergism and attenuation of Aconitum,such as reducing cardiac toxicity,retaining its pharmacological activities such as antirheumatic arthritis,safe use and forensic inference of poisoning,and to look forward to the application prospect of Aconi-tum.
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