Research Progress on Reducing Resistance of Immune Checkpoint Inhibitors with Traditional Chinese Medicine
The resistance to immune checkpoint inhibitors(ICIs)presents a critical challenge that necessitates immediate at-tention.Currently,modern medicine lacks effective solutions for this issue.Traditional Chinese medicine(TCM),on the other hand,is known for its attributes of low toxicity,minimal side effects and notable therapeutic efficacy.When integrated with mod-ern medicine,TCM demonstrates a positive role across various aspects of tumor treatment.Consequently,exploring potential breakthroughs in the realm of TCM becomes a worthwhile pursuit to enhance the effectiveness of ICIs while minimizing their toxic-ity.This review article aimed to outline the recent advancements in understanding the mechanisms underlying ICIs resistance and highlighted the groundbreaking progress achieved by TCM in overcoming this resistance.Through comprehensive analysis and synthesis of the existing research,this review aimed to contribute valuable insights to TCM potential in mitigating resistance to ICIs.
traditional Chinese medicineimmune checkpoint inhibitorsdrug resistanceimmunity