Effects of Acupoint Catgut Embedding Combined with Bushen Jiedu Tongluo Formula(补肾解毒通络汤)on Renal Function in Diabetes Nephropathy Rats Based on p38 MAPK/CREB Signal Pathway
Objective Based on the signal pathway of mitogen activated protein kinase p38(MAPK)/cAMP response element binding protein(CREB),the effect of acupoint catgut embedding on renal function in diabetes nephropathy rats was investigated.Methods The model of diabetes nephropathy was established in SD rats.Interventions were conducted separately with only grasp-ing(model group),Bushen Jiedu Tongluo Formula group,acupoint catgut embedding[Zusanli(ST36),Shenshu(BL23),Zhong-wan(RN12)]and Bushen Jiedu Tongluo Formula(catgut embedding group).After 3 weeks of intervention,it observed the renal weight/body weight,urine creatinine,blood creatinine,peripheral glycated hemoglobin,fibrinogen(FN)content,morphological differences in renal cortex as well as the expressions of p-p38MAPK,p-CREB and FN proteins in the renal cortex of rats.Re-sults The renal weight/body weight,blood and urine creatinine,glycosylated hemoglobin,serum FN and renal cortex p-p38MAPK,p-CREB and FN protein expressions of each group showed statistical significance(P＜0.001).Compared with those of the model group,the above indicators of the catgut embedding group were significantly reduced(P＜0.05).Moreover,the a-bove indicators of the catgut embedding group were significantly lower than those of the Bushen Jiedu Tongluo Formula group(P＜0.05).Conclusion Acupoint catgut embedding at Zusanli(ST36),Shenshu(BL23)and Zhongwan(RN12)combined with Bushen Jiedu Tongluo Formula can significantly improve hyperglycemia and renal damage in diabetes nephropathy.This may be achieved by regulating the p38 MAPK/CREB signaling pathway.
diabetes nephropathyacupoint catgut embeddingmitogen activated protein kinase p38cAMPresponsive ele-ment binding protein
万方数据
维普
