Efficacy of Wendan Decoction(温胆汤)Combined with Clomipramine in Treatment of Obsessive-Compulsive Disorder
Objective To study the efficacy and safety of Wendan Decoction(温胆汤)combined with clomipramine in the treatment of obsessive-compulsive disorder.Methods A total of 310 patients diagnosed with obsessive-compulsive disorder were divided into two groups according to random number table,155 cases treated with clomipramine were assigned into the refer-ence group and 155 cases treated with Wendan Decoction combined with clomipramine were assigned into the study group.The clinical efficacy of the two groups was observed and compared.Results Five cases fell off in each group and 150 cases were com-pared in each group.The total effective rate of the study group(96.67％)was higher than that(76.33％)of the reference group and the adverse reaction rate(10.67％)of the study group was lower than that(28.67％)of the reference group.The difference was statistically significant(P＜0.05).Compared with those of the reference group,the scores of Yale-Brown obsessive-com-pulsive scale(Y-BOCS)and clinical global impression(CGI)of the study group were lower,and the difference was statistically significant(P＜0.05).Compared with those of the reference group,Hamilton Depression Rating Scale(HAMD-24)scores,Hamilton Anxiety Rating Scale(HAMA)scores,social functional rating scale(SFRS)scores and Pittsburgh sleep quality index(PSQI)scores of the study group were lower,and the differences were statistically significant(P＜0.05).Conclusion The pa-tients diagnosed as obsessive-compulsive disorder were treated with clomipramine and Wendan Decoction in combination,and the clinical effect was significant,which could effectively improve the clinical symptoms of patients with high safety and clinical application value.
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