目的 研究针刺、穴位埋线联合治疗过敏性鼻炎的疗效及对炎症因子白介素-4(interleukin-4,IL-4),白介素-6(interleukin-6,IL-6),白介素-10(interleukin-10,IL-10)的影响.方法 选取 2021 年 6 月-2022 年 6 月医院诊治的过敏性鼻炎患者106例作为研究对象,根据随机数字表法均分为两组,对照组53例、观察组53例.对照组进行穴位埋线治疗,观察组采用针刺、穴位埋线联合治疗.治疗4周后观察两组患者的疗效,炎症因子IL-4、IL-6、IL-10水平变化,生活质量以及不良反应情况.结果 观察组、对照组总有效率分别为98.11％、84.91％,观察组显著高于对照组,差异有统计学意义(P＜0.05).治疗前,两组患者炎症因子IL-4、IL-6、IL-10水平差异无统计学意义(P＞0.05),治疗后,两组IL-4、IL-6水平均显著下降,IL-10水平显著升高差异有统计学意义(P＜0.05),并且观察组IL-4、IL-6水平显著低于对照组,IL-10水平显著高于对照组差异有统计学意义(P＜0.05).治疗前两组鼻结膜炎生活质量调查问卷(rhinoconjunctivitis quality of life questionnaire,RQLQ)评分差异均无统计学意义(P＞0.05),治疗后两组 RQLQ 各维度评分及总分均显著降低差异有统计学意义(P＜0.05),且观察组RQLQ鼻部症状、眼部症状评分及总分显著低于对照组,差异有统计学意义(P＜0.05).观察组、对照组不良反应发生率分别为9.43％、5.66％,组间差异无统计学意义(P＞0.05).结论 针刺、穴位埋线联合治疗过敏性鼻炎的疗效显著,并且能够显著改善炎症因子水平及患者生活质量,同时保证良好的安全性,具有临床应用价值.
Curative Effect of Acupuncture with Acupoint Catgut Embedding in Treatment of Allergic Rhinitis and Its Effect on Inflammatory Factors IL-4,IL-6 and IL-10
Objective To study the curative effect of acupuncture with acupoint catgut embedding in the treatment of allergic rhinitis and its effect on inflammatory factors interleukin-4(IL-4),interleukin-6(IL-6)and interleukin-10(IL-10).Methods A total of 106 patients with allergic rhinitis diagnosed and treated in the hospital from June 2021 to June 2022 were se-lected as the research objects.According to the random number table method,they were divided into two groups,53 cases in the control group and 53 cases in the observation group.The control group was treated with acupoint catgut embedding,and the ob-servation group was treated with acupuncture and acupoint catgut embedding.After 4 weeks of treatment,the efficacy of the two groups,the changes of inflammatory factors IL-4,IL-6,IL-10,the quality of life and adverse reactions were observed.Results The total effective rates of the observation group and the control group were 98.11％and 84.91％,and the rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,the levels of IL-4 and IL-6 in the two groups decreased significantly,and the level of IL-10 increased significantly(P＜0.05).The levels of IL-4 and IL-6 in the observation group were significantly lower than those in the control group,and the level of IL-10 was significantly higher than that in the control group(P＜0.05).There was no significant difference in the scores of rhinoconjunctivitis quality of life questionnaire(RQLQ)between the two groups before treatment(P＞0.05).After treatment,the scores of each dimension and total score of RQLQ in the two groups were significantly decreased(P＜0.05),and the scores of nasal symptoms,ocular symptoms and total score of RQLQ in the observation group were significantly lower than those in the control group(P＜0.05).The incidence of adverse reactions in the observation group and the control group was 9.43％and 5.66％,and there was no significant difference between the two groups(P＞0.05).Conclusion The combination of acupuncture and acupoint catgut embedding is effective in the treatment of allergic rhinitis,and can significantly improve the lev-els of inflammatory factors and the quality of life of patients,while ensuring good safety,which has clinical application value.
allergic rhinitisacupunctureacupoint catgut embeddingcurative effectinflammatory factorsquality of lifead-verse reactions
万方数据
维普
